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Bio
My research is focused on fundamental structural molecular biology, specifically in the measurement of the conformational dynamics of proteins and the elucidation of the role that these motions play in protein folding and misfolding of both water-soluble and membrane proteins. Using a wide range of biophysical methods and combining these with protein chemistry, molecular biology, chemical biology and structural biology, my research focus over the last 30 years has been the delineation of the mechanisms by which proteins fold or misfold; how dynamic excursions enable proteins to self-associate into amyloid fibrils - the complex macromolecular assemblies associated with some of the deadliest human diseases; and how proteins fold into the bacterial outer membranes of Gram-negative organisms.
Research Interests
Papers共 506 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of the American Chemical Societyno. 18 (2024): 12702-12711
biorxiv(2024)
Liam D. Aubrey,Natalia Ninkina,Sabine M. Ulamec,Natalia Y. Abramycheva,Eftychia Vasili, Oliver M. Devine,Martin Wilkinson, Eilish Mackinnon,Galina Limorenko,Martin Walko, Sarah Muwanga,Leonardo Amadio,
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 2 (2024): e2309700120-e2309700120
Chalmers C. Chau, Christopher M. Maffeo,Aleksei Aksimentiev,Sheena E. Radford,Eric W. Hewitt,Paolo Actis
Nature Communicationsno. 1 (2024): 4403-4403
Katherine M Dewison, Ben Rowlinson,Jonathan M Machin, Joel A Crossley, Dev Thacker,Martin Wilkinson, Sabine E Ulamec,G Nasir Khan,Neil A Ranson, Patricija van-Oosten Hawle,David J Brockwell,Sheena Radford
crossref(2024)
The EMBO Journalno. 1 (2024): 1-13
Methods in Cell Biology (2024): 249-292
Nature Communicationsno. 1 (2024): 1-16
Leon F. Willis,Vishal Toprani, Sashini Wijetunge,Annette Sievers,Laura Lin, Jeanine Williams, Tom J. Crowley,Sheena E. Radford,Nikil Kapur,David J. Brockwell
JOURNAL OF PHARMACEUTICAL SCIENCESno. 3 (2024): 625-636
Angewandte Chemie International Editionno. 34 (2023)
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