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个人简介
Dr. Sockanathan’s lab team uses the developing spinal cord and brain as major paradigms to define the mechanisms that maintain an undifferentiated progenitor state and that trigger their differentiation into neurons and glia. Her more recent work explores pathways that preserve neuronal survival in the adult nervous system and investigates how their dysfunction contributes to neurodegenerative disease.
The major focus of the lab is the study of a new family of six-transmembrane proteins (6-TM GDEs) that play key roles in regulating cellular differentiation and neuronal survival. Dr Sockanathan's lab discovered that the 6-TM GDEs release GPI-anchored proteins from the cell surface through cleavage of the GPI-anchor. This discovery identified the 6-TM GDEs as the first vertebrate membrane bound GPI-cleaving enzymes that work at the cell surface to regulate GPI-anchored protein function. Current work in the lab involves defining how the 6-TM GDEs regulate cellular signaling events that control neuronal and glial differentiation and function, with a major focus on how GDE dysfunction relates to the onset and progression of disease. To solve these questions, they utilize an integrated approach that includes in vivo models, imaging, molecular biology, biochemistry, developmental biology, genetics and behavior.
The major focus of the lab is the study of a new family of six-transmembrane proteins (6-TM GDEs) that play key roles in regulating cellular differentiation and neuronal survival. Dr Sockanathan's lab discovered that the 6-TM GDEs release GPI-anchored proteins from the cell surface through cleavage of the GPI-anchor. This discovery identified the 6-TM GDEs as the first vertebrate membrane bound GPI-cleaving enzymes that work at the cell surface to regulate GPI-anchored protein function. Current work in the lab involves defining how the 6-TM GDEs regulate cellular signaling events that control neuronal and glial differentiation and function, with a major focus on how GDE dysfunction relates to the onset and progression of disease. To solve these questions, they utilize an integrated approach that includes in vivo models, imaging, molecular biology, biochemistry, developmental biology, genetics and behavior.
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论文共 37 篇作者统计合作学者相似作者
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Yanxia Guo,Karina Pino-Lagos,Cory A. Ahonen,Kathy A. Bennett,Jinshan Wang,Joseph L. Napoli, Rune Blomhoff,Shanthini Sockanathan, Roshantha A. Chandraratna,Ethan Dmitrovsky,Mary Jo Turk,Randolph J. Noelle
crossref(2023)
Yanxia Guo,Karina Pino-Lagos,Cory A. Ahonen,Kathy A. Bennett,Jinshan Wang,Joseph L. Napoli, Rune Blomhoff,Shanthini Sockanathan, Roshantha A. Chandraratna,Ethan Dmitrovsky,Mary Jo Turk,Randolph J. Noelle
crossref(2023)
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