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A critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation.
To address this, we are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits in vitro and in vivo.
We introduced the use of instructive signals for deriving from human pluripotent stem cells self-organizing 3D cellular structures named brain region-specific spheroids/organoids. We demonstrated that these cultures, such as the ones resembling the cerebral cortex, can be reliably derived across many lines and experiments, contain synaptically connected neurons and non-reactive astrocytes, and can be used to gain mechanistic insights into genetic and environmental brain disorders. Moreover, when maintained as long-term cultures, they recapitulate an intrinsic program of maturation that progresses towards postnatal stages.
To address this, we are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits in vitro and in vivo.
We introduced the use of instructive signals for deriving from human pluripotent stem cells self-organizing 3D cellular structures named brain region-specific spheroids/organoids. We demonstrated that these cultures, such as the ones resembling the cerebral cortex, can be reliably derived across many lines and experiments, contain synaptically connected neurons and non-reactive astrocytes, and can be used to gain mechanistic insights into genetic and environmental brain disorders. Moreover, when maintained as long-term cultures, they recapitulate an intrinsic program of maturation that progresses towards postnatal stages.
Research Interests
Papers共 203 篇Author StatisticsCo-AuthorSimilar Experts
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Cellno. 1 (2024): 8-13
HAEMATOLOGICAno. 3 (2024): 948-952
Massimo M Onesto,Neal D Amin, Chenjie Pan,Xiaoyu Chen,Noah Reis,Alfredo M Valencia, Zuzana Hudacova,James P McQueen,Marc Tessier-Lavigne,Sergiu P Paşca
bioRxiv : the preprint server for biology (2024)
Ji-il Kim,Kent Imaizumi,Mayuri Vijay Thete, Zuzana Hudacova, Ovidiu Jurjuţ,Neal D. Amin,Grégory Scherrer,Sergiu P. Paşca
bioRxiv the preprint server for biology (2024)
Kevin W Kelley,Omer Revah,Felicity Gore, Konstantin Kaganovsky,Xiaoyu Chen,Karl Deisseroth,Sergiu P Pașca
Nature protocols (2024)
biorxiv(2024)
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Author Statistics
#Papers: 199
#Citation: 10388
H-Index: 43
G-Index: 101
Sociability: 7
Diversity: 0
Activity: 4
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