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A critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation.
To address this, we are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits in vitro and in vivo.
We introduced the use of instructive signals for deriving from human pluripotent stem cells self-organizing 3D cellular structures named brain region-specific spheroids/organoids. We demonstrated that these cultures, such as the ones resembling the cerebral cortex, can be reliably derived across many lines and experiments, contain synaptically connected neurons and non-reactive astrocytes, and can be used to gain mechanistic insights into genetic and environmental brain disorders. Moreover, when maintained as long-term cultures, they recapitulate an intrinsic program of maturation that progresses towards postnatal stages.
To address this, we are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits in vitro and in vivo.
We introduced the use of instructive signals for deriving from human pluripotent stem cells self-organizing 3D cellular structures named brain region-specific spheroids/organoids. We demonstrated that these cultures, such as the ones resembling the cerebral cortex, can be reliably derived across many lines and experiments, contain synaptically connected neurons and non-reactive astrocytes, and can be used to gain mechanistic insights into genetic and environmental brain disorders. Moreover, when maintained as long-term cultures, they recapitulate an intrinsic program of maturation that progresses towards postnatal stages.
研究兴趣
论文共 118 篇作者统计合作学者相似作者
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Cellno. 1 (2024): 8-13
Xiao Yang,Csaba Forró,Thomas L. Li,Yuki Miura, Tomasz J. Zaluska,Ching-Ting Tsai,Sabina Kanton, James P. McQueen,Xiaoyu Chen,Valentina Mollo,Francesca Santoro,Sergiu P. Pașca,
Ji-Il Kim, Kent Imaizumi,Mayuri Vijay Thete, Zuzana Hudacova, Ovidiu Jurjuţ,Neal D Amin,Grégory Scherrer,Sergiu P Paşca
bioRxiv : the preprint server for biology (2024)
Xiaoyu Chen,Fikri Birey,Min-Yin Li,Omer Revah,Rebecca Levy,Mayuri Vijay Thete,Noah Reis, Konstantin Kaganovsky,Massimo Onesto,Noriaki Sakai, Zuzana Hudacova, Jin Hao,
Natureno. 8009 (2024): 818-825
Aaron Gordon,Se-Jin Yoon, Lucy K. Bicks,Jacqueline M Martin,Greta Pintacuda, Stephanie A Arteaga,Brie A Wamsley,Qiuyu Guo, Lubayna Elahi,Ricardo E Dolmetsch,Jonathan A Bernstein, Ruth O'Hara,
biorxiv(2024)
bioRxiv : the preprint server for biology (2023)
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Ji-il Kim,Yuki Miura,Min-Yin Li,Omer Revah,Sridhar Selvaraj,Fikri Birey,Xiangling Meng,Mayuri Vijay Thete, Sergey D. Pavlov,Jimena Andersen,Anca M. Paşca,Matthew H. Porteus,
crossref(2023)
NATUREno. 7982 (2023): 359-+
Zhisong He,Leander Dony,Jonas Simon Fleck, Artur Szalata, Katelyn X. Li, Irena Sliskovic,Hsiu-Chuan Lin,Malgorzata Santel,Alexander Atamian,Giorgia Quadrato, Jieran Sun,Sergiu P Pasca,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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