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Main research area: Eliminative signaling by interferons (IFN) and proteolysis of the interferon alpha receptor (IFNAR1). This receptor plays an essential role in anti-tumorigenic and immunomodulatory effects of Type I IFN. Agents targeting the regulators of the Type I IFN pathway are often used in therapy of cancers. Enzymatic regulators of IFNAR1 fate include specific protein kinases, phosphatases, E3 ubiquitin ligases and de-ubiquitinating enzymes. We are determined to identify and characterize these regulators and to use this knowledge for stabilization of IFNAR1 and reactivation of specific IFNAR1-dependent effects that stimulate anti-cancer immune responses and improve the efficacy of anti-cancer therapies.
研究兴趣
论文共 109 篇作者统计合作学者相似作者
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Molecular cancer research : MCRno. 4 (2024): 360-372
Elizabeth L. Hardaker,Emilio Sanseviero,Ankur Karmokar, Devon Taylor,Marta Milo, Chrysis Michaloglou,Adina Hughes, Mimi Mai,Matthew King,Anisha Solanki,Lukasz Magiera,Ricardo Miragaia,
Fan Yang, Md Naushad Akhtar,Duo Zhang,Rakan El-Mayta, Junyoung Shin,Jay F Dorsey,Lin Zhang,Xiaowei Xu,Wei Guo, Stephen J Bagley,Serge Y Fuchs,Constantinos Koumenis,
Science advancesno. 9 (2024): eadj4678-eadj4678
Duo Zhang,Albert M Li, Guanghui Hu, Menggui Huang,Fan Yang,Lin Zhang,Kathryn E Wellen,Xiaowei Xu,Crystal S Conn,Wei Zou, Mark Kahn,Seth D Rhoades,
Cancer researchno. 16 (2023): 2790-2806
Charline Ogier, Akino Mercy Charles Solomon,Zhen Lu,Ludmila Recoules,Alena Klochkova, Linara Gabitova-Cornell,Battuya Bayarmagnai,Diana Restifo,Aizhan Surumbayeva,Debora B Vendramini-Costa,Alexander Deneka,Ralph Francescone,
bioRxiv : the preprint server for biology (2023)
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