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Research Interests
Dr. Faucher is studying the tools use by bacteria to infect humans and animals through consumption of water and food.
Members of the Faucher lab have a focused interest on the behaviour of bacterial pathogens in non-clinical environments, such as in water. Survival and perhaps growth of water-borne pathogen in this environment is crucial for its transmission to its host. Our aim is to understand the genetic factors and environmental factors that influence water-borne pathogens behaviour in the non-clinical environment and their transmission to humans. We are also investigating how this environment influence evolution of these pathogens.
Model organisms are Legionella pneumophila and Campylobacter jejuni. L. pneumophila is a ubiquitous habitant of natural and human-made water systems and is transmitted to human by inhalation of contaminated aerosols, generated by cooling towers, showers and other devices. Quebec City suffered from a major Legionella outbreak in the summer 2012, resulting in 183 cases and 13 deaths. C. jejuni causes severe intestinal infection in humans and is associated with Guillain-Barré syndrome, an autoimmune disease that can lead to life-threatening neuronal damage. Poultry and cattle are carriers of C. jejuni and transmission to humans is associated with consumption of uncooked meat, unpasteurized dairy product and contaminated water.
Current Research
Genetics of water-borne pathogens: L. pneumophila grows in water system by infecting unicellular host cells, such as ciliates and protozoa. Dr. Faucher is using transcriptomic to uncover the mechanism underlying long-term survival in water and growth in host cells. Dr. Faucher also studies the survival of Campylobacter in water systems and the role of ciliates in the packaging of Campylobacter, which improves its resistance to disinfectant.
Evolution of water-borne pathogens: Microbial control strategies apply an evolutionary pressure on water-borne pathogen. Dr. Faucher is using in vitro experimental evolution to dissect the evolutionary path leading to increase resistance to disinfection strategy and improved virulence properties.
Microbial diversity in water systems: Dr. Faucher also studies the effect of environmental conditions and the role of resident microbiome on the growth of L. pneumophila in real and model water systems by using metagenome sequencing. He is also interested in mining the water microbiome for novel molecules and finding microbes that can be used as biocontrol agents to protect water systems.
Detection of L. pneumophila in water systems: The current methods available to detect L. pneumophila in water are inadequate to monitor its presence in real time. Therefore, Dr. Faucher and his colleagues are developing DNA aptamers for in situ rapid detection of L. pneumophila.
Dr. Faucher is studying the tools use by bacteria to infect humans and animals through consumption of water and food.
Members of the Faucher lab have a focused interest on the behaviour of bacterial pathogens in non-clinical environments, such as in water. Survival and perhaps growth of water-borne pathogen in this environment is crucial for its transmission to its host. Our aim is to understand the genetic factors and environmental factors that influence water-borne pathogens behaviour in the non-clinical environment and their transmission to humans. We are also investigating how this environment influence evolution of these pathogens.
Model organisms are Legionella pneumophila and Campylobacter jejuni. L. pneumophila is a ubiquitous habitant of natural and human-made water systems and is transmitted to human by inhalation of contaminated aerosols, generated by cooling towers, showers and other devices. Quebec City suffered from a major Legionella outbreak in the summer 2012, resulting in 183 cases and 13 deaths. C. jejuni causes severe intestinal infection in humans and is associated with Guillain-Barré syndrome, an autoimmune disease that can lead to life-threatening neuronal damage. Poultry and cattle are carriers of C. jejuni and transmission to humans is associated with consumption of uncooked meat, unpasteurized dairy product and contaminated water.
Current Research
Genetics of water-borne pathogens: L. pneumophila grows in water system by infecting unicellular host cells, such as ciliates and protozoa. Dr. Faucher is using transcriptomic to uncover the mechanism underlying long-term survival in water and growth in host cells. Dr. Faucher also studies the survival of Campylobacter in water systems and the role of ciliates in the packaging of Campylobacter, which improves its resistance to disinfectant.
Evolution of water-borne pathogens: Microbial control strategies apply an evolutionary pressure on water-borne pathogen. Dr. Faucher is using in vitro experimental evolution to dissect the evolutionary path leading to increase resistance to disinfection strategy and improved virulence properties.
Microbial diversity in water systems: Dr. Faucher also studies the effect of environmental conditions and the role of resident microbiome on the growth of L. pneumophila in real and model water systems by using metagenome sequencing. He is also interested in mining the water microbiome for novel molecules and finding microbes that can be used as biocontrol agents to protect water systems.
Detection of L. pneumophila in water systems: The current methods available to detect L. pneumophila in water are inadequate to monitor its presence in real time. Therefore, Dr. Faucher and his colleagues are developing DNA aptamers for in situ rapid detection of L. pneumophila.
研究兴趣
论文共 74 篇作者统计合作学者相似作者
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Jinha Suh,Bridget O'Brien, Paul D. Glenn Ii, Zhangbin Cai,France Daigle,Sebastien P. Faucher,Jennifer Ronholm
PeerJ (2024): e17197-e17197
MICROBIOLOGY SPECTRUMno. 1 (2024): e0302423-e0302423
APPLIED AND ENVIRONMENTAL MICROBIOLOGYno. 9 (2023): e0066623-e0066623
Microbiology spectrumno. 2 (2023)
Jiale Liang,Sébastien P. Faucher
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Jin Jun Liang,Sébastien P. Faucher
Authorea (Authorea) (2023)
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作者统计
#Papers: 76
#Citation: 2278
H-Index: 24
G-Index: 47
Sociability: 5
Diversity: 0
Activity: 1
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