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职业迁徙
个人简介
My research revolves around microbe-induced host cell reprogramming by effector proteins that are shuttled into plant cells. Effectors are a hallmark for animal and plant pathogens’ success in conquering the host. Plant populations frequently maintain counter-defensive disease resistance proteins (R proteins) for intracellular recognition of effectors. Studying R protein mechanisms thus reveals plant strategies in coping with constant pathogen challenge.
During my masters and Ph.D. studies with Thomas Lahaye in Halle I characterised the tomato TIR-NB-LRR protein Bs4. Bs4 confers resistance towards the bacterial pathogen Xanthomonas campestris pv vesicatoria [1]. Xanthomonads are the causal agents of economically important bacterial plant diseases in tomato, pepper, citrus and rice. Tomato Bs4-mediated resistance is achieved by cytoplasmic recognition of a set of Xanthomonas-translocated transcription activator-like (TAL) effector proteins [2].
TAL effectors have a striking structure with central repeats and transcription activation domain and localise to host cell nuclei. They basically represent transcription factors that induce a set of host genes which in turn affect host physiology and development to support Xanthomonas infection. During a short postdoc following my Ph.D. in the same lab, I studied the TAL effector AvrHah1 [3].
I was intrigued by how these TAL effectors find their specific target gene promoters. The similarity of AvrHah1 to existing effectors together with other data obtained in the labs of Prof. Ulla Bonas and Prof. Thomas Lahaye enabled my colleague Jens Boch and me to break a fundamental code of DNA-binding specificity [4,5]. This discovery led to generation of customised TAL activators and nucleases with unrivalled DNA binding specificity that are now frequently being exploited in biomedicine as illustrated by a flurry of publications. I am trying to keep up with these in my blog: www.scoop.it/t/tal-effector-science.
My next stop was the group of Sophien Kamoun at the Sainsbury Laboratory in Norwich, where I studied the interactions of plants and oomycetes. I primarily use cell biology approaches to study Phytophthora infestans, the Irish potato famine pathogen in Nicotiana benthamiana [6]. I contributed to understanding of trafficking and function of the phylogenetically ancient class of Crinkler effectors. It was surprising to find that despite their diversity they all target the host nucleus [7]. I then continued my interest in studying P. infestans effectors that contribute to the development and maintenance of dedicated accommodation structures formed between microorganism and plant cell, called haustoria [8].
研究兴趣
论文共 54 篇作者统计合作学者相似作者
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Enoch Lok Him Yuen,Yasin Tumtas, Lok I Chan, Tarhan Ibrahim,Edouard Evangelisti,Frej Tulin,Jan Sklenar,Frank Menke,Sophien Kamoun,Doryen Bubeck,Sebastian Schornack,Tolga O Bozkurt
biorxiv(2024)
Yen-Ting Lu,Jeanne Loue-Manifel, Norbert Bollier, Philippe Gadient, Freya De Winter,Philip Carella,Antoine Hoguin, Shona Grey-Switzman, Hugo Marnas, Francois Simon, Alice Copin, Shelby Fischer,
Current biology : CBno. 4 (2024): 793-807.e7
The Plant cell (2024)
Cell Host & Microbeno. 5 (2023): 683-684
Trends in plant science (2023)
Environmental Microbiologyno. 11 (2022): 5524-5533
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