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Molecular mechanisms for wiring the brain
The overall goal of the Millard lab is to understand how specificity is generated in the brain. This problem is best exemplified by considering that 100 trillion synapses are generated and maintained in the human brain using a toolkit of only 20,000 genes. We have been approaching this problem using molecular genetics in the fruit fly, Drosophila melanogaster. Most projects in the lab revolve around how a broadly expressed cell surface protein, called Down syndrome cell adhesion molecule 2 (Dscam2), is able to perform specific functions in different neurons. We are also interested in mechanisms of neurological disease, particularly those that involve changes in synaptic function.
Molecular mechanisms for wiring the brain
The overall goal of the Millard lab is to understand how specificity is generated in the brain. This problem is best exemplified by considering that 100 trillion synapses are generated and maintained in the human brain using a toolkit of only 20,000 genes. We have been approaching this problem using molecular genetics in the fruit fly, Drosophila melanogaster. Most projects in the lab revolve around how a broadly expressed cell surface protein, called Down syndrome cell adhesion molecule 2 (Dscam2), is able to perform specific functions in different neurons. We are also interested in mechanisms of neurological disease, particularly those that involve changes in synaptic function.
研究兴趣
论文共 34 篇作者统计合作学者相似作者
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Giang Thanh Nguyen-Dien,Brendan Townsend,Prajakta Kulkarni,Keri-Lyn Kozul, Soo Siang Ooi, Denaye Eldershaw,Saroja Weeratunga, Meihan Liu,Mathew JK Jones,S Sean Millard,Dominic CH Ng,Michele Pagano,
biorxiv(2024)
Giang Thanh Nguyen‐Dien,Keri‐Lyn Kozul,Yi Cui,Brendan Townsend, Prajakta Gosavi Kulkarni, Soo Siang Ooi,Antonio Marzio,Nissa Carrodus,Steven Zuryn,Michele Pagano,Robert G. Parton,Michael Lazarou,
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Sarah K Kerwin,Nissa Carrodus, Amber Kewin,Tian Lin, Xiaoyu Qian,Allan McRae,Jian Yang,Brett M. Collins,Naomi Wray,Fleur Garton,Sean Millard
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Julia Pagan, Giang Nguyen-Dien,Keri Kozul,Yi Cui,Brendan Townsend, Soo Siang Ooi,Michele Pagano,Michael Lazarou,Robert Taylor,Brett M. Collins,Robert G. Parton,Prajakta Kulkarni,
biorxiv(2022)
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