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Bio
Dr. Murphy's work focuses on the immune response to complex infectious diseases and on diagnostic test development. The major focus of the laboratory is malaria infection of humans and animal models by Plasmodium parasites. There is currently no approved vaccine to prevent malaria infection. However, for the past 40 years, it has been known that humans and animals can be protected against later infections when experimentally immunized with repeated doses of attenuated Plasmodium sporozoites, the form of the parasite that is transmitted by female Anopheles mosquitoes. The protective immune responses induced by these kind of immunizations remain largely unknown because it is extremely difficult to simultaneously monitor responses against hundreds of potential antigens. Using novel high–throughput T cell screening technologies developed in collaboration with Dr. Brad Stone, Dr. Murphy’s group studies the complex poly–specific T cell repertoire induced by Plasmodium sporozoites using mouse models of malaria infection. The laboratory is also exploring novel methods to experimentally induce broadly protective immune responses against malaria using synthetic biology–based T cell vaccines.
Research Interests
Papers共 35 篇Author StatisticsCo-AuthorSimilar Experts
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EMBO molecular medicineno. 4 (2024): 723-754
Felicia N. Watson,Melanie J. Shears,Anya C. Kalata,Caroline J. Duncombe, A. Mariko Seilie,Chris Chavtur, Ethan Conrad,Irene Cruz Talavera,Andrew Raappana,D. Noah Sather,Sumana Chakravarty,B. Kim Lee Sim,
Scientific Reportsno. 1 (2024): 1-16
Yining Zhu, Jingyao Ma, Ruochen Shen,Jinghan Lin, Shuyi Li,Xiaoya Lu,Jessica L. Stelzel,Jiayuan Kong,Leonardo Cheng,Ivan Vuong,Zhi-Cheng Yao, Christine Wei,
PLOS NEGLECTED TROPICAL DISEASESno. 10 (2023): e0011652-e0011652
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