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Dr. Stuart Dryer’s laboratory studies physiological and pathophysiological processes that occur in the kidney. The current research focuses on the role of ion channels and receptors in the regulation of cells that form the glomerular filtration barrier, and the proximal tubule. The lab has recently focused on a Ca2+-permeable cation channel known as TRPC6. Mutations that cause gain of function in these channels lead to devastating genetic forms of kidney disease. Dryer’s lab is interested in understanding the normal function and regulation of TRPC6 channels, including the factors that activate their gating and abundance at the cell surface. They are also interested in the role of TRPC6 in driving non-genetic forms of glomerular disease.
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Onur K Polat,Elena Isaeva,Yashwanth R Sudhini, Brenna Knott,Ke Zhu,Manuel Noben,Varsha Suresh Kumar,Nicole Endlich,Steve Mangos, Tejasree Vallapu Reddy,Beata Samelko,Changli Wei,
Frontiers in allergy (2022): 835776
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