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My global interest is how the central nervous system controls movement. Specifically, how we produce coordinated and rhythmic movements, such as movement, chewing and breathing, is a little-known basic problem in neuroscience. These basic types of exercise we take for granted may be affected during injury or illness. My lab uses animal models to study how to produce rhythmic jaw movement. We combine electrophysiological, molecular and pharmacological techniques with computational modeling and bioinformatics to solve the basic problem of how single and small neural networks in the brain stem coordinate the coordinated activities in synapses and ion channels to produce unique discharge patterns in rhythmic processes. Sports. We found that the local neuron group in the brainstem region is important for the basic rhythm components of chewing, and specific ion channels are activated to produce appropriate discharge patterns, reminiscent of chewing patterns. Recently, the laboratory obtained transgenic mice, which produce most of the symptoms of the destructive disease amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig disease. We found that some ion channels in sensory neurons and motor neurons were abnormally active before the onset of disease symptoms. Although these studies are still at an early stage, they can provide insight into how neurodegeneration of motor neurons leading to paralysis and death occurs,
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Neurobiology of disease (2020): 104877-104877
mag(2015)
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