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Career Trajectory
Bio
My current research focuses on understanding how transcriptional programing in the early stages of adjuvant vaccine or infectious stimulus contributes to the generation of protective cellular immunity. Both my doctoral work and experience as a technician have given me excellent training in biochemical, molecular, and immunological techniques to pursue this project. Following graduation from college I worked as a technician in the lab of Paul Lieberman where I was responsible for developing and then running a high throughput biochemical screen of chemical inhibitors of Epstein-Bar Virus latency. In addition to gaining further training as a biochemist and cell biologist. Having developed an interest in immunology, I pursued my Ph.D. training with Dr. Jordan Jacobelli, an expert in studying lymphocyte migration with advanced microscopy techniques, including multi-photon microscopy. My work in Dr. Jacobelli’s lab focused on understanding the regulation of lymphocyte motility by cytoskeletal effector proteins. During this work I gained extensive training in cellular immunology, the cell biology of the cytoskeleton, and in advanced imaging techniques, such as 2-photon microscopy. My doctoral work uncovered a novel role for the cytoskeletal effector FMNL1 in promoting the T cell migration across restrictive endothelial barriers. Additionally, I discovered previously unknown roles for the cytoskeletal effectors MyoIIA and mDia1 in regulating leukemia engraftment and dissemination. My work in Dr. Jacobelli’s lab studying lymphocyte migration and motility gave me an appreciation for the dynamic nature of T cells and the importance of location in shaping an immune response. My experience has also given me the tools necessary to investigate how changes at the molecular level (i.e. the actin cytoskeleton) can have impacts at a cellular and organismal level in a number of murine models of human disease. Currently I am seeking to apply my training and skills in immunological, cellular, molecular, and microscopy techniques to the study of T cell memory formation.
Research Interests
Papers共 49 篇Author StatisticsCo-AuthorSimilar Experts
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Daria L. Ivanova,Scott B. Thompson,Jared Klarquist, Michael G. Harbell,Augustus M. Kilgore, Erika L. Lasda,Jay R. Hesselberth,Christopher A. Hunter,Ross M. Kedl
JOURNAL OF IMMUNOLOGYno. 1 (2022): 122.28-122.28
Jared Klarquist,Eric W. Cross,Scott B. Thompson,Benjamin Willett,Daniel L. Aldridge, Alayna Caffrey-Carr, Zheming Xu,Christopher A. Hunter,Andrew Getahun,Ross M. Kedl
Social Science Research Network (2021)
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