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The focus of his current work is elucidating the molecular mechanisms by which vascular remodelling is initiated and propagated. Key cellular events include phenotypic switching of vascular smooth muscle cells (SMCs) and the role of oxidative stress, extracellular vesicles and calcification. In this, he collaborates closely with the Cardiothoracic Surgery and Vascular Surgery departments of the Heart and Vessel Center (HVC) of the Maastricht University Medical Center. Patient derived primary SMCs are isolated from vascular tissue and induced pluripotent stem cells (iPSC) are generated from patient derived peripheral blood mononuclear cells (PBMCs). These iPSCs are used to differentiate into patient specific cardiovascular cells (i.e., cardiomyocytes, smooth muscle cells, endothelial cells and fibroblasts) to study cardiovascular disease.
The underlying causes of SMC phenotypic switching are insufficient to understand the pathogenesis of vascular ageing and calcification at a level that allows development of novel diagnostic tools and therapeutic strategies. In his project line, the Schurgers’ group aim to elucidate the molecular mechanisms of vitamin K-metabolism in health and vascular disease. Importantly, this work will help to understand the paradoxal observation that patients with low vitamin K-status during oral anticoagulant treatment develop enhanced vascular calcification and our results might provide new insights in prognostic and preventive measures to combat vascular ageing.
Professor Schurgers is Chairman of the steering scientific board on the world-wide quality assurance scheme for vitamin K detection and member of the scientific advisory boards of the Dutch Thrombosis Society.
The underlying causes of SMC phenotypic switching are insufficient to understand the pathogenesis of vascular ageing and calcification at a level that allows development of novel diagnostic tools and therapeutic strategies. In his project line, the Schurgers’ group aim to elucidate the molecular mechanisms of vitamin K-metabolism in health and vascular disease. Importantly, this work will help to understand the paradoxal observation that patients with low vitamin K-status during oral anticoagulant treatment develop enhanced vascular calcification and our results might provide new insights in prognostic and preventive measures to combat vascular ageing.
Professor Schurgers is Chairman of the steering scientific board on the world-wide quality assurance scheme for vitamin K detection and member of the scientific advisory boards of the Dutch Thrombosis Society.
Research Interests
Papers共 429 篇Author StatisticsCo-AuthorSimilar Experts
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Nephrology Dialysis Transplantationno. Supplement_1 (2024)
R. Tobal,J. Potjewijd, F. Vries, D. P.C. Doorn,A. Jaminon, R. Bittner, C. Akbulut, V. Empel,P. Heeringa, J. Damoiseaux,L. Schurgers, P. Paassen
crossref(2024)
Sofia de la Puente Secades, Dustin Mikolajetz,Nathalie Gayrard,Vera Jankowski,Khaleda Alghamdi,Angel Argiles Ciscart,Leon Schurgers,Donald Ward, Joachim Jankowski,Setareh Orth-Alampour
Nephrology Dialysis Transplantationno. Supplement_1 (2024)
Titus P. Lemmens, Vanessa Bröker, Minke Rijpkema,Christopher C.W. Hughes,Leon J. Schurgers,Judith M.E.M. Cosemans
Thrombosis Research (2024): 179-190
Shaiv Parikh, Anne Wehrens,Alessandro Giudici,Berta Ganizada, Pepijn Saraber,Leon J. Schurgers,Gijs Debeij,Ehsan Natour, Jos G. Maessen,Wouter Huberts,Tammo Delhaas,Koen D. Reesink,
crossref(2024)
Basic research in cardiologyno. 3 (2024): 371-395
Serhat Kabak,Ryan E. Accord, Shaynah Wanga,Shaiv Parikh,Berta Ganizada,Roberto Lorusso, Jos G. Maessen,Leon J. Schurgers,Tammo Delhaas,Koen Reesink,Elham Bidar
crossref(2024)
ANNALS OF NUTRITION AND METABOLISM (2023): 59-60
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