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Dr. Sadegh-Nasseri and her lab made the notable discovery that binding of peptides to MHC class II induces different conformations, a finding that has formed the basis for how peptide-MHC class II complexes are recognized and edited by the MHC class II accessory molecules. They have maintained a leading role in understanding mechanisms in peptide binding and the role of MHC class II accessory molecules, HLA-DM and HLA-DO in peptide exchange and editing. The team also reported the first cell free reductionist antigen processing system that identifies immunodominant epitopes from protein antigens for recognition by helper T cells. This system has led to the discovery that antigen presentation for pathogens and autoantigens follow divergent paths, a finding that has significant impact in our understanding of antigen presentation to helper T cells.
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论文共 127 篇作者统计合作学者相似作者
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FRONTIERS IN IMMUNOLOGY (2024): 1304798-1304798
Journal of Immunologyno. 1 (2023): 221.15-221.15
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Jian Guan,J David Peske, Michael Manoharan Valerio,Chansu Park, Ellen A Robey,Scheherazade Sadegh-Nasseri
eLifeno. 1_Supplement (2023): 150.09-150.09
Adrian Martin-Esteban, Jesus Contreras Rodriguez,David J. Peske,Jose Antonio Lopez de Castro,Nilabh Shastri,Scheherazade Sadegh-Nasseri
Journal of Immunologyno. 1 (2023): 221.16-221.16
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Frontiers in Immunology (2023): 1277609
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Jian Guan, Michael Manoharan Valerio,J. David Peske,Chansu Park,Ellen A. Robey,Scheherazade Sadegh-Nasseri,Nilabh Shastri
JOURNAL OF IMMUNOLOGYno. 1 (2023)
Jesus Contreras Rodriguez, Adrian Martin Esteban,J. David Peske,Nilabh Shastri,Scheherazade Sadegh-Nasseri
Journal of Immunologyno. 1 (2023): 221.23-221.23
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