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My laboratory focuses on the molecular basis of population heterogeneity in Mycobacterium tuberculosis (Mtb) and the extent to which differences between mycobacterial cells contribute to differences in disease and treatment outcomes. Our work combines bacterial genetic approaches with high throughput methodologies including population genomics, ssRNAseq and quantitative live cell imaging to define the molecular mechanisms by which Mtb generates diversity and how this diversity enables the bacterium to survive subsequent selective forces including antibiotics and immune selection. We further seek to understand the impact of host immune responses on the interaction of Mtb with the infected host, again working at both single cell and genomic levels. My work engages a broad network of collaborators including experts in technologies to assess single cell behavior at MIT and MGH, experts in sequencing methodologies at the Broad Institute and experts in human immunology at the Ragon Institute, where I am the outgoing Director of the TB Program.
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论文共 171 篇作者统计合作学者相似作者
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Proceedings of the National Academy of Sciences of the United States of Americano. 14 (2024): e2403321121-e2403321121
Sydney Stanley, Xin Wang,Qingyun Liu, Young Yon Kwon, Abigail M. Frey,Nathan D. Hicks,Andrew J. Vickers,Sheng Hui,Sarah M. Fortune
PLOS PATHOGENSno. 2 (2024): e1012050-e1012050
Cheng Bei,Junhao Zhu, Peter H Culviner,Mingyu Gan, Eric J Rubin,Sarah M Fortune, Qian Gao,Qingyun Liu
Cecilia A Webber, Virginia J Glick, Morgan Martin, Cecilia Kim, Maryam Ahmad, Lauren E Simmons,Sunghee Bang,Michael C Chao, Nicole C Howard,Sarah M Fortune,Lalit K Beura, Seo Yoon Lee,
biorxiv(2024)
Leela R L Davies,Chuangqi Wang, Pia Steigler, Kathryn A Bowman, Stephanie Fischinger,Mark Hatherill, Michelle Fisher,Stanley Kimbung Mbandi, Miguel Rodo,Tom H M Ottenhoff, Hazel M Dockrell, Jayne S Sutherland,
Nature microbiologypp.1-13, (2024)
Caylin G Winchell,Sarah K Nyquist,Michael C Chao,Pauline Maiello,Amy J Myers,Forrest Hopkins,Michael Chase,Hannah P Gideon,Kush V Patel,Joshua D Bromley, Andrew W Simonson, Roisin Floyd-O'Sullivan,
The Journal of experimental medicineno. 12 (2023)
JOURNAL OF BIOLOGICAL CHEMISTRYno. 11 (2023): 105312-105312
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