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Bio
Dr. Regina Santella's research involves the use of biomarkers for the detection of human exposure to environmental and occupational carcinogens in molecular epidemiology studies to identify causative factors, susceptible populations, and preventive interventions. Her work has allowed the determination of exposure to carcinogens by the measurement of their binding to DNA with highly specific and sensitive immunoassays using monoclonal and polyclonal antibodies that her laboratory has developed. These studies have demonstrated higher levels of DNA damage in those with environmental or occupational exposures and in subjects with breast, lung, and liver cancer compared to controls. The role of genetic susceptibility in cancer risk is also being investigated with an emphasis on DNA repair capacity. Current studies seek to understand the role of environmental/lifestyle factors on epigenetic changes in DNA methylation and microRNA expression, how they impact cancer risk as well as whether epigenetic changes can be used for early diagnosis of cancer.
Research Interests
Papers共 615 篇Author StatisticsCo-AuthorSimilar Experts
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HEPATOLOGY (2024)
Hepatology (Baltimore, Md.)no. 1 (2024): 87-101
Sasinya N. Scott, Marvin Siguencia,Frank Z. Stanczyk,Michaela F. Hartmann,Stefan A. Wudy,Melissa White,Wendy K. Chung,Regina M. Santella,Mary Beth Terry,Lauren C. Houghton
JOURNAL OF THE ENDOCRINE SOCIETYno. 3 (2024): bvad161-bvad161
Xu Hua,Hui Zhou, Hui-Chen Wu, Julia Furnari, Corina P Kotidis,Raul Rabadan,Jeanine M Genkinger, Jeffrey N Bruce, Peter Canoll,Regina M Santella,Zhiguo Zhang
Nature communicationsno. 1 (2024): 6113-6113
Research square (2023)
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