The Ong Lab investigates a range of research topics, all of which center on deciphering the molecular mechanisms of cardiovascular disease and dysfunction and using this information to develop potential therapeutic strategies. Toward this end, we use human induced pluripotent stem cells as a platform to study the pathogenesis of cardiovascular diseases through cellular, genetic, and biochemical approaches. We are particularly interested in cardiometabolic diseases with a focus on mitochondrial biology. We also employ clinical samples and rodent models for our studies as additional validation steps.