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个人简介
Information processing in the brain occurs at synapses, and defects in synapse formation are likely to underlie many neurological and psychiatric diseases. We are therefore interested in the molecules and structures that regulate synapse formation. For most of our studies, we have used the skeletal neuromuscular junction, because it is the best studied of all synapses and therefore a good subject for molecular analysis of developmental processes. Our major aim has been to identify components that mediate intercellular interactions: molecules that muscle cells use to trigger presynaptic differentiation of axons, molecules that axons use to organize postsynaptic differentiation of muscle, and receptors than transduce these signals. To learn which of the proteins we find are the functionally critical ones, we combine studies of dissociated nerve and muscle cells in vitro with molecular genetic analysis of knockout mice in vivo. A second project extends this analysis to the vertebrate central nervous system. We have chosen the retinotectal projection because of its relative accessibility, and initiated studies of how retinal axons arborize and synapse in specific laminae. Such laminar restrictions are major determinants of specific connectivity in many parts of the brain, including the cerebral cortex. Our hope is to apply insights and reagents obtained from the neuromuscular junction to the more complicated, but perhaps even more interesting, synapses of the brain. Finally, in pursuit of these aims, we are engaged in generating novel transgenic strains that make it possible to visualize neurons and their connections in developing and adult animals, and in animal models of neurological and psychiatric disease.
研究兴趣
论文共 340 篇作者统计合作学者相似作者
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Jin Li,Jongsu Choi,Xuesen Cheng,Justin Ma, Shahil Pema,Joshua R Sanes, Graeme Mardon,Benjamin J Frankfort,Nicholas M Tran,Yumei Li, Rui Chen
iScienceno. 6 (2024): 109916-109916
Lin Zhang, Martina Cavallini, Junqiang Wang, Ruiqi Xin,Qiangge Zhang,Guoping Feng,Joshua R. Sanes,Yi - Rong Peng
Andrew R. Hamel,Wenjun Yan,John M. Rouhana,Aboozar Monovarfeshani,Xinyi Jiang,Puja A. Mehta,Jayshree Advani,Yuyang Luo,Qingnan Liang,Skanda Rajasundaram, Arushi Shrivastava, Katherine Duchinski,
Nature Communicationsno. 1 (2024): 396-396
Jin Li,Jun Wang,Ignacio L Ibarra,Xuesen Cheng,Malte D Luecken,Jiaxiong Lu,Aboozar Monavarfeshani,Wenjun Yan,Yiqiao Zheng,Zhen Zuo, Samantha Lynn Zayas Colborn, Berenice Sarahi Cortez,
Research squareno. 8 (2023)
Andreas Liu,Elliott S Milner,Yi-Rong Peng, Hannah A Blume, Michael C Brown,Gregory S Bryman,Alan J Emanuel,Philippe Morquette,Nguyen-Minh Viet,Joshua R Sanes,Paul D Gamlin,Michael Tri H Do
Axel Guskjolen,Jagroop Dhaliwal,Juan de la Parra,Jonathan R. Epp,Sangyoon Ko,Erin Chahley, Mitch de Snoo, Michela Solari, Prabdeep Panesar,Jason Snyder,Xin Duan,Joshua R. Sanes,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Joshua Hahn,Aboozar Monavarfeshani,Mu Qiao, Allison Kao,Yvonne Kölsch,Ayush Kumar,Vincent P Kunze,Ashley M Rasys, Rose Richardson,Herwig Baier,Robert J Lucas,Wei Li,
bioRxiv : the preprint server for biologypp.1-15, (2023)
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