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His research focused on signaling events elicited by metabolites and nuclear hormone receptors. He characterized metabolic effects of bile acids and defined a novel bile acid signaling pathway that affects energy homeostasis. For his second postdoctoral fellowship, Dr. Houten returned to the Academic Medical Center of the University of Amsterdam and combined his interest in regulation of metabolic processes and human genetics. He initiated a line of research on the pathophysiology of mitochondrial fatty acid oxidation defects and was promoted to Principal Investigator. He applied state-of-the-art phenotyping methods to mouse models for mitochondrial fatty acid oxidation defects, which yielded new and unexpected insights in the pathophysiology of hypoglycemia and cardiac hypertrophy associated with these disorders.
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Papers共 265 篇Author StatisticsCo-AuthorSimilar Experts
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Molecular genetics and metabolismno. 1 (2024): 108351-108351
Molecular Genetics and Metabolismno. 4 (2024): 108174
Ruoxi Wu,Susmita Khamrui, Tetyana Dodatko,João Leandro, Amanda Sabovic, Sara Violante,Justin R Cross, Eric Marsan, Kunal Kumar,Robert J DeVita, Michael B Lazarus,Sander M Houten
ACS chemical biologyno. 7 (2024): 1544-1553
crossref(2023)
Mehdi Yeganeh,Christiane Auray-Blais,Bruno Maranda, Amanda Sabovic,Robert J DeVita,Michael B Lazarus,Sander M Houten
Journal of inherited metabolic diseaseno. 5 (2023): 931-942
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