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Our goal is to understand the fundamental principles that control the specification and connectivity of spinal neurons involved in locomotion, particularly motor neurons. Over the long term these studies should provide insight into the basic principles involved in the proper formation of the nervous system, as well as provide practical information for treatments of spinal cord injury and diseases like amyotrophic lateral sclerosis, post polio syndrome, and spinal muscle atrophy. The approaches used in the lab include experiments with genetically modified mice, developmental studies with chicken embryos, and differentiation assays with ES cells. Currently the lab has three areas of investigation: the mechanisms that control gene regulation during neuronal fate specification, the analysis of axon guidance, and studies of the central pattern generator circuitry involved in locomotion.
Our goal is to understand the fundamental principles that control the specification and connectivity of spinal neurons involved in locomotion, particularly motor neurons. Over the long term these studies should provide insight into the basic principles involved in the proper formation of the nervous system, as well as provide practical information for treatments of spinal cord injury and diseases like amyotrophic lateral sclerosis, post polio syndrome, and spinal muscle atrophy. The approaches used in the lab include experiments with genetically modified mice, developmental studies with chicken embryos, and differentiation assays with ES cells. Currently the lab has three areas of investigation: the mechanisms that control gene regulation during neuronal fate specification, the analysis of axon guidance, and studies of the central pattern generator circuitry involved in locomotion.
Research Interests
Papers共 126 篇Author StatisticsCo-AuthorSimilar Experts
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Yu Wu, Benjamin A. Temple, Nicole Sevilla, Jiaao Zhang,Hanlin Zhu,Pavlo Zolotavin,Yifu Jin,Daniela Duarte, Elischa Sanders,Eiman Azim,Axel Nimmerjahn,Samuel L. Pfaff,
Cell Reportsno. 5 (2024): 114199-114199
bioRxiv the preprint server for biology (2023)
Liezl Maree, Eric Leonardis,Sergei Gepshtein,Thomas Albright,Kristianna Hitchcock, Nick Andrews, Eiman Azim,Samuel Pfaff, Christian Metallo,Talmo Pereira
Biological Psychiatryno. 9 (2023): S7-S7
Natureno. 7982 (2023): 383-392
eLife (2022)
Lydia Daboussi,Giancarlo Costaguta,Miriam Gullo, Nicole Jasinski, Veronica Pessino, Brendan O’Leary,Karen Lettieri,Shawn Driscoll,Samuel L. Pfaff
Cell Reportsno. 11 (2022): 113282-113282
Neuronno. 24 (2022): 4090-4107.e11
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Author Statistics
#Papers: 127
#Citation: 17821
H-Index: 60
G-Index: 127
Sociability: 7
Diversity: 0
Activity: 0
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