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He discovered that inactivating mutations of BAP1 and PBRM1, two epigenetic and tumor suppressor genes in clear-cell renal cell carcinoma, were mutually exclusive, resulting in biomarkers of different patient prognosis. These breakthroughs were later confirmed by many other investigators and are progressively being used in clinical practice to stratify kidney cancer patients and guide clinical decision making. His team is currently aiming to elucidate the molecular mechanism of tumor aggressiveness and metastasis caused by mutations in BAP1 and trying to identify genetic vulnerabilities of BAP1 loss that could be exploited therapeutically.
His research interests are on translational cancer research, cancer genomics, and tumor metastasis.
His research interests are on translational cancer research, cancer genomics, and tumor metastasis.
Research Interests
Papers共 57 篇Author StatisticsCo-AuthorSimilar Experts
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Smiths Sengkwawoh Lueong,Martin Metzenmacher,Gregor Zaun, Gina Lauren Mayer, Erik Jan Hemmer,Katharina Lückerath,Kelsey Pomykala,Balazs Hegedüs,Peter A. Horn,Marija Trajkovic-Arsic,Tibor Szarvas,Renáta Váraljai,
Cancer Researchno. 6_Supplement (2024): 5019-5019
Monika Raab,Izabela Kostova,Samuel Pena-Llopis,Daniela Fietz,Monika Kressin, Seyed Mohsen Aberoumandi,Evelyn Ullrich,Sven Becker,Mourad Sanhaji,Klaus Strebhardt
Jetsy Montero-Vergara, Kira Plachetta,Lisa Kinch,Stephan Bernhardt, Kriti Kashyap,Beth Levine,Lipi Thukral,Martina Vetter,Christoph Thomssen,Stefan Wiemann,Samuel Peña-Llopis,Verena Jendrossek,
Cell Death & Diseaseno. 1 (2024): 1-11
ANTICANCER RESEARCHno. 7 (2023): 3374-3375
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Autophagy and CancerMethods in Molecular Biologypp.75-98, (2022)
Single Nucleotide Polymorphismspp.185-195, (2022)
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Author Statistics
#Papers: 58
#Citation: 3719
H-Index: 23
G-Index: 45
Sociability: 6
Diversity: 3
Activity: 78
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