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个人简介
He discovered that inactivating mutations of BAP1 and PBRM1, two epigenetic and tumor suppressor genes in clear-cell renal cell carcinoma, were mutually exclusive, resulting in biomarkers of different patient prognosis. These breakthroughs were later confirmed by many other investigators and are progressively being used in clinical practice to stratify kidney cancer patients and guide clinical decision making. His team is currently aiming to elucidate the molecular mechanism of tumor aggressiveness and metastasis caused by mutations in BAP1 and trying to identify genetic vulnerabilities of BAP1 loss that could be exploited therapeutically.
His research interests are on translational cancer research, cancer genomics, and tumor metastasis.
His research interests are on translational cancer research, cancer genomics, and tumor metastasis.
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论文共 61 篇作者统计合作学者相似作者
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Autophagy and CancerMethods in Molecular Biologypp.75-98, (2022)
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