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My group investigates why the aged brain is vulnerable to neurodegeneration and asks whether we can alleviate this susceptibility. We focus on the role of key homeostatic neural-circuit plasticity processes thought to be critical for healthy network function.
After graduating from Oxford University in 2006 I was awarded an MRC Capacity building Ph.D. studentship at King’s College London to investigate synaptic connection loss and neural plasticity in the cortex. I then completed a post-doc investigating how homeostatic plasticity regulates neural activity in the adult visual cortex at University College London. In October 2015, I won the Edmond J Safra Fellowship which supports early career researchers during their transition to independence. In April 2018 I was awarded a UK Dementia Research Institute Fellowship and became a lecturer in the Division of Brain Sciences at Imperial College London. Here, I use a combination of in vivo voltage and calcium imaging, bioelectronics and electrophysiology to investigate the neural-circuit plasticity factors that make the aged brain susceptible to neurodegeneration and ultimately dementia.
After graduating from Oxford University in 2006 I was awarded an MRC Capacity building Ph.D. studentship at King’s College London to investigate synaptic connection loss and neural plasticity in the cortex. I then completed a post-doc investigating how homeostatic plasticity regulates neural activity in the adult visual cortex at University College London. In October 2015, I won the Edmond J Safra Fellowship which supports early career researchers during their transition to independence. In April 2018 I was awarded a UK Dementia Research Institute Fellowship and became a lecturer in the Division of Brain Sciences at Imperial College London. Here, I use a combination of in vivo voltage and calcium imaging, bioelectronics and electrophysiology to investigate the neural-circuit plasticity factors that make the aged brain susceptible to neurodegeneration and ultimately dementia.
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Nature neuroscienceno. 12 (2023): 2158-2170
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Erik Nutma,Nurun Fancy,Maria Weinert,Stergios Tsartsalis,Manuel C Marzin,Robert C J Muirhead, Irene Falk,Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman,Jasper Anink,
Nature communicationsno. 1 (2023): 5247-5247
Javier Rueda-Carrasco,Dimitra Sokolova,Sang-Eun Lee,Thomas Childs, Natália Jurčáková,Gerard Crowley,Sebastiaan De Schepper,Judy Z Ge, Joanne I Lachica,Christina E Toomey,Oliver J Freeman,John Hardy,
The EMBO journalno. 19 (2023)
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Abbas Dehghan,Rui Climaco Pinto,Ibrahim Karaman,Jian Huang,Brenan R Durainayagam,Mohsen Ghanbari, Areesha Nazeer, Qi Zhong,Sonia Liggi,Luke Whiley,Rima Mustafa,Miia Kivipelto,
Seminars in Cell & Developmental Biology (2022): 35-54
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