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个人简介
Dr. Thiagalingam is an expert cancer geneticist and was the first to show that SMAD4 inactivation is a critical event during the late stages of colon cancer progression. He was a lead researcher in the team that first identified a family of five novel SMAD genes. He also proposed a simple minded multi-modular molecular network (MMMN) cancer progression model as a road map to visualize the various gene alterations in modules of networks of pathways. Recently, his studies found that intact hyperactive TGFß-Smad signaling is required to sustain “epigenetic memory” responsible for epithelial-mesenchymal transition (EMT), a critical step during conversion to malignant cancer. His long-term goal is to identify novel cancer biomarkers and therapeutic targets by contributing to the “big picture” of interconnected network of events that mediate cancer progression to metastasis using breast and colon cancers as the model systems.
研究兴趣
论文共 118 篇作者统计合作学者相似作者
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crossref(2023)
Genesno. 7 (2023): 1506-1506
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作者统计
#Papers: 119
#Citation: 12455
H-Index: 38
G-Index: 111
Sociability: 6
Diversity: 1
Activity: 1
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