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My team studies the molecular and physiological pathways involved in the regulation of human appetite and body weight and their disruption in obesity. Some of the molecular pathways involved in regulating weight also regulate blood pressure and lipid metabolism, and affect an individual's risk of cardiovascular diseases.
One of the links between obesity and cardiovascular disease is leptin. We have identified mutations in leptin gene using candidate gene approach in patients with severe, early onset obesity, and have demonstrated that leptin contributes to hypertension in obese individuals. These results suggest that pharmacological approaches that modulate leptin’s effects on cells could represent a useful therapeutic strategy for the treatment of obesity-associated hypertension and might help prevent a subset of obesity-associated cardiovascular disease.
One of the links between obesity and cardiovascular disease is leptin. We have identified mutations in leptin gene using candidate gene approach in patients with severe, early onset obesity, and have demonstrated that leptin contributes to hypertension in obese individuals. These results suggest that pharmacological approaches that modulate leptin’s effects on cells could represent a useful therapeutic strategy for the treatment of obesity-associated hypertension and might help prevent a subset of obesity-associated cardiovascular disease.
Research Interests
Papers共 388 篇Author StatisticsCo-AuthorSimilar Experts
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Science advancesno. 10 (2024): eadj3823-eadj3823
SCIENCE ADVANCESno. 10 (2024)
Science advancesno. 26 (2024): eadl2675-eadl2675
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2024)
Aliki Perdikari, Virgil A Woods,Ali Ebrahim,Katherine Lawler,Rebecca Bounds, Nathanael I Singh, Tamar Skaist Mehlman,Blake T Riley,Shivani Sharma, Jackson W Morris,Julia M Keogh,Elana Henning,
bioRxiv the preprint server for biology (2024)
Annales d'Endocrinologieno. 5 (2023): 669-669
The New England journal of medicineno. 24 (2023): 2253-2261
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Author Statistics
#Papers: 390
#Citation: 51798
H-Index: 99
G-Index: 227
Sociability: 8
Diversity: 3
Activity: 149
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