My research interests are focused on the molecular genetics and genomics of gastric and colorectal cancers. We have performed comprehensive molecular profiling and integrative genomic studies on a large series of gastric and colorectal cancers using next-generation sequencing, expression microarray, methylation array and DNA SNP genotyping array. Our studies reveal the complex genomic landscape of gastric cancer and first identified many new gastric cancer driver genes. Examples include frequent mutation of ARID1A, a chromatic remodelling gene, in gastric cancers with MSI or EBV, and hotspot mutation of RHOA in diffuse type gastric cancer. Integrative genomic analysis revealed molecular subtype-specific patterns of genetic and epigenetic perturbations, many of them converging to target the same key cancer driver genes or pathways.