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Bio
Whelan also studies the viral life cycle of VSV to identify potential antiviral targets. He identified a specific subunit of the ribosome, RPL40, as being essential to initiate translation of VSV mRNAs. This selective mechanism allows the virus to block translation of host mRNAs without preventing the production of its own proteins. Interfering with this mechanism could lead to antiviral therapies. With Stephen C. Harrison, he used cryo-EM to determine the structure of the L protein of VSV, revealing several potential drug targets.
Research Interests
Papers共 189 篇Author StatisticsCo-AuthorSimilar Experts
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Chieh-Yu Liang,Saravanan Raju,Zhuoming Liu,Yuhao Li, Guha Asthagiri Arunkumar,James Brett Case,Suzanne M Scheaffer,Seth J Zost, Cory M Acreman,Matthew Gagne,Shayne F Andrew, Deborah Carolina Carvalho Dos Anjos,
Natureno. 8018 (2024): 950-960
Chieh-Yu Liang,Saravanan Raju,Zhuoming Liu,Yuhao Li, Guha A. Arunkumar,James Brett Case,Seth J. Zost, Cory M. Acreman, Deborah Carolina Carvalho dos Anjos,Jason S. McLellan,James E. Crowe,Sean P.J. Whelan,
biorxiv(2024)
Erika Garay,Sean P. J. Whelan,Rebecca M. Dubois,Sara M. O'Rourke, Angel Eduardo Salgado-Escobar,Jose Esteban Munoz-Medina,Carlos F. Arias,Susana Lopez
JOURNAL OF CLINICAL VIROLOGY PLUSno. 1 (2023)
Wenjuan Dong,Jing Wang,Lei Tian,Jianying Zhang,Erik W Settles,Chao Qin, Daniel R Steinken-Kollath,Ashley N Itogawa,Kimberly R Celona,Jinhee Yi, Mitchell Bryant,Heather Mead,
Nature communicationsno. 1 (2023): 1936-1936
Cell reports. Medicineno. 12 (2023): 101305-101305
biorxiv(2023)
Journal of clinical virology plusno. 1 (2023): 100135-100135
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