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个人简介
Research Interests
Identifying and cataloging all gene sequences and their corresponding protein high-resolution static 3-dimensional structures is only a prelude to the real challenges of future biological inquiries. We need to understand the dynamic structural changes of isolated macromolecules undergoing biochemical reactions. We need to identify transient interactions between macromolecules. We need to decipher the cell circuitry and its detailed time-dependent responses to various stimuli. We need to decode intracellular and extracellular communication signals and the corresponding molecular-level responses of live cells, tissues and whole organs. Analytical tools will need to be developed in order to identify and measure these molecular conformations and interactions. High-sensitivity fluorescence methods will play a vital role in this endeavor because they offer many advantages for probing isolated molecules and molecules in live cells, tissues and organs. Fluorescence is non-invasive; it provides imaging and sectioning capabilities in three dimensions; it has high sensitivity, down to the single molecule level, and it allows the observation of molecular- and organelle-specific signals. Our group develops and applies ultrahigh-resolution, ultrahigh-sensitivity fluorescence imaging and spectroscopy tools to solving outstanding problems in biology.
研究兴趣
论文共 448 篇作者统计合作学者相似作者
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bioRxiv the preprint server for biology (2024)
Adan Marzouq,Lion Morgenstein, Carlos A. Huang-Zhu,Shimon Yudovich,Ayelet Atkins,Asaf Grupi, Reid C. Van Lehn,Shimon Weiss
Nature communicationsno. 1 (2024): 134-134
Proceedings of SPIE--the International Society for Optical Engineering (2023)
JOURNAL OF PHYSICAL CHEMISTRY LETTERSno. 10 (2023): 2702-2707
Debjit Roy,Xavier Michalet, Kiran Bharadwaj,Evan W Miller,Yijie Wang,Arjun Deb,Michael A Wayne,Claudio Bruschini,Edoardo Charbon, Mahbanoo Vakili,Robert Gunsalus,Robert T Clubb,
Biophysical Journalno. 3 (2022): 139-139
Benjamin Ambrose, Victoria E. Hill,Robert A. Shaw,Tristan Johnston-Wood,Matthew Willmott, Callum Johnston,Rebecca Mächtel,Thorben Cordes,Eitan Lerner,J.G. Hill,Shimon Weiss,Timothy D. Craggs
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作者统计
#Papers: 447
#Citation: 40572
H-Index: 75
G-Index: 199
Sociability: 7
Diversity: 0
Activity: 1
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