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Fluid dynamic and transport aspects of arterial disease, bioheat transfer, cellular mechanisms for mechanotransduction, bone fluid flow, microcirculatory exchange, transport in kidney proximal tubule, basic fluid mechanics, porous media flow. Professor Weinbaum has published more than 200 full length journal papers plus numerous shorter communications and conference papers. His research has involved important collaborations with other investigators and institutions.
His joint studies with the UC San Diego have investigated the cellular origins of the permeability of arterial endothelium to low density lipoproteins, transport models for the arterial intima and the formation of subendothelial liposomes. His studies in bioheat transfer have examined the development of a fundamental bioheat equation to describe microvascular blood-tissue heat transfer (Weinbaum-Jiji equation) and the application of bioheat models to describe heat transfer in muscle tissue, limbs, rat tail and finger. His joint studies with the UC Davis have attempted to elucidate the structural pathways through the interendothelial cleft that determine capillary permeability and osmotic forces. His joint studies with S. C. Cowin have explored the cellular transduction mechanism by which bone cells detect mechanically induced strains and communicate these strains to the bone forming cells. His studies with Weill-Cornell Medical School have led to a new hypothesis for the mechanosensory mechanism that leads to the glomerulotubular balance in the kidney. Most recently, he has proposed a new hypothesis for vulnerable plaque rupture due to cellular micro-calcifications in thin fibrous caps which were detected for the first time and a jet train which flies on a soft porous track within centimeters of the ground at speeds approaching 700km/hr.
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Andrea Corti,Annalisa De Paolis, Pnina Grossman, Phuc A Dinh,Elena Aikawa,Sheldon Weinbaum,Luis Cardoso
Biomechanics of Coronary Atherosclerotic Plaquepp.381-409, (2021)
Proceedings of the National Academy of Sciences of the United States of Americano. 14 (2021)
Archive of Biomedical Science and Engineeringno. 1 (2020): 041-042
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