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Bio
For more than ~30 years, my work has focused on the analysis of the fundamental mechanisms by which macrophage differentiation facilitates or restricts infectious agents or tumor growth. My laboratory has made seminal contributions to the area of immunology that we now call “innate immunity,” and specifically, the mechanisms by which Toll-like receptor (TLR) signaling is regulated. We have characterized many of the fundamental mechanisms by which TLR agonists, such as Gram negative lipopolysaccharide (LPS), and cytokines and interferons regulate macrophage functions. Moreover, we have used a model of "endotoxin tolerance" to study the regulation of such signaling pathways.
The creative use of genetic, molecular, and biochemical approaches, combined with unique animal models of infection, has led to our most recent, highly translational work, resulting in novel therapeutic approaches for influenza and respiratory syncytial virus (RSV), development of small molecule TLR antagonists based on the structural interactions of innate signaling molecules, and a prototype vaccine for the biothreat agent, Francisella tularensis.
In toto, I have published ~300 peer-reviewed publications plus ~50 invited works, have mentored 35 post-doctoral fellows and 11 graduate students, and am currently director of a T32 entitled “Signaling pathways in innate immunity.” I have had continuous NIH funding for more than 34 years, including a "NIH Merit Award," in addition to other sources of grant support. Collectively, my record shows that I have developed the scientific expertise and leadership skills required to direct multiple concurrent projects, multi-component projects, and a training program.
Research Interests
Papers共 641 篇Author StatisticsCo-AuthorSimilar Experts
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The Journal of pharmacology and experimental therapeuticspp.JPET-AR, (2024)
S.P. Atamas,V. Lockatell,N.W. Todd, J.C. Papadimitriou, V. Rus, K.N. Lugkey,S.N. Vogel, V.Y. Toshchakov,I.G. Luzina
A68. UNVEILING NOVEL AVENUES IN IPF THERAPIES (2024)
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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