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个人简介
Personal Statement
The mission of the Hemato- and Immunopathology laboratory at Amsterdam UMC is: i) to advance the insight into the fundamental biological processes underlying B cell development and cell migration; ii) to exploit this knowledge to improve the diagnosis and treatment of B cell lymphomas and multiple myeloma.
From bench to bedside: “We are exploring the interactions between malignant B cells and plasma cells with their microenvironment since these represent the Achilles’ heel of these cancers” Malignant Lymphoma and Multiple Myeloma (MM) are common cancers with a high patient morbidity and mortality. Genetic defects in concert with cues from the tumor microenvironment activate signaling pathways that drive tumor growth, survival, and dissemination. Targeting these pathways by drugs and monoclonal antibodies can open new therapeutic venues.
Our research has identified B-cell receptor (BCR) signaling as key regulator of B cell adhesion and migration and as target for the treatment of B cell lymphoma. Importantly, we demonstrated that ibrutinib, a clinically highly active Bruton's tyrosine kinase (BTK) inhibitor, which has recently been FDA approved for the treatment of mantle cell lymphoma, chronic lymphocytic leukemia (CLL), and Waldenström macroglobulinemia (WM), acts by targeting migration of lymphoma cells to and retention in their niches, leading to cell death by anoikis (homelessness). Furthermore, we identified syndecan-1 as a crucial regulator of tumor-microenvironment interaction in MM and demonstrated that deregulated HGF/MET and WNT signaling contributes to malignant behavior in this cancer.
研究兴趣
论文共 364 篇作者统计合作学者相似作者
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Hildo C Lantermans, Fangxue Ma,Annemieke Kuil,Sanne van Kesteren, Sevtap Yasinoglu,Guang Yang,Sara J Buhrlage,Jinhua Wang,Nathanael S Gray,Marie José Kersten,Steven P Treon,Steven T Pals,
Leukemiano. 7 (2024): 1570-1580
Patrick RG Eriksen,Fleur de Groot,Erik Clasen-Linde,Peter de Nully Brown, Ruben de Groen,Linea C. Melchior,Andrea D Maier,Marthe Minderman,Joost S. P. Vermaat,Christian von Buchwald,Steven T. Pals,Steffen Heegaard
Blood Advancesno. 8 (2024): 1946-1957
Hildo C. Lantermans, Fangxue Ma,Annemieke Kuil,Sanne van Kesteren, Sevtap Yasinoglu,Guang Yang,Sara J. Buhrlage,Jinhua Wang,Nathanael S. Gray,Marie José Kersten,Steven P. Treon,Steven T. Pals,
Leukemiapp.1-11, (2024)
crossref(2023)
Marina Knudsen Kirkegaard,Marthe Minderman,Lene Dissing Sjö,Steven T Pals,Patrick R G Eriksen,Steffen Heegaard
Blood Cancer Journalno. 1 (2023)
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