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Dr. Carmichael’s laboratory studies the molecular and cellular mechanisms of neural repair after stroke and other forms of brain injury. This research focuses on the processes of axonal sprouting and neural stem cell responses after stroke, and on neural stem cell transplantation. Stroke is the leading cause of adult disability. This is because 75% of people survive their initial stroke, but few recover completely. My laboratory is studying the mechanisms of brain repair and functional recovery after stroke. Recent research has led to the surprising discoveries that the adult brain is capable of forming new connections after stroke (termed axonal sprouting) and is capable of recruiting adult brain stem cells to areas of injury (termed post-stroke neurogenesis). If properly harnessed, these two processes hold the promise of regenerating and reconnecting brain cells near areas of injury. We are determining the molecules that control axonal sprouting and neurogenesis, so that new therapies can be developed that promote brain repair after stroke. The fact that the adult brain is capable of axonal sprouting and neurogenesis after stroke indicates that stroke induces a region of great structural change, or plasticity, near areas of damage. In a third avenue of investigation, my laboratory is identifying these areas of brain plasticity after stroke as candidate regions for neural stem cell transplantation to promote recovery and restoration of function after stroke.
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Naohiko Okabe, Mary Hovanesyan, Srbui Azarapetian,Weiye Dai,Batsheva Weisinger, Ana Parabucki,Shira Reznik Balter,Esther Shohami, Yaron Segal,S. Thomas Carmichael
CELL TRANSPLANTATION (2023): 2-2
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Miguel A. Marin,Amy J. Gleichman,Xiaofei Wei,Daniel S. Whittaker,Istvan Mody, Christopher S. Colwell,S. Thomas Carmichael
The Journal of Neuroscienceno. 48 (2023): 8126-8139
Nature Reviews Bioengineeringpp.1-20, (2023)
Annals of neurologyno. 6 (2023): 1005-1007
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