I use neuroimaging techniques to understand more about the brain mechanisms involved in the symptoms of schizophrenia – both the 'positive symptoms' (unusual experiences such as hallucinations and paranoia) that are characteristic of episodes of psychosis, and the 'secondary' symptoms that affect memory and attention, and make it difficult for people to interact socially and sustain relationships.
I aim to use that knowledge to aid the development of new, effective treatments for the large number of people with schizophrenia who do not respond to antipsychotic medication. 20-45% of patients experience significant 'positive' symptoms despite optimal antipsychotic treatment, and 'secondary' symptoms are largely unresponsive to conventional treatment.
I also lead, and collaborate on, commercial clinical trials testing the effectiveness of medication and other new therapies.
I head the Cognition, Schizophrenia and Imaging Laboratory (CSI Lab), housed in the Department of Psychosis Studies at the Institute of Psychiatry, Psychology & Neuroscience, King’s College London.
My research is carried out in collaboration with the Lab's junior researchers and students; with clinicians who are keen to get involved in research and use the results to inform their practice; and with affiliated colleagues based in universities around the world.