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As a pharmacologist I have been involved in mediators of physio-pathological process studies, particularly in hypertension and inflammation. I described the pharmacological profile of the bradykinin potentiating factor (BPF) present in the venom of the Brazilian snake, Bothrops jararaca. This factor was constituted by a family of peptides possessing bradykinin-potentiating activity and inhibitory effect on angiotensin I conversion. With our elucidation of the structure and the synthesis of the Bothrops active pentapeptide, I did the pioneer demonstration of its effectiveness in controlling high blood pressure in angiotensin-dependent models of hypertension. This study paved the way for development of the highly successful new class of antihypertensive drugs, the inhibitors of the conversion of angiotensin I. I participated in the first demonstration of the inhibition of the synthesis of prostaglandins by aspirin-like drugs and proposed the present accepted mechanism of their analgesic action. Recently, I described a cascade of cytokines responsible for the release of hyperalgesic mediators and contributed to the understanding of the molecular bases of the nociceptor sensitization. I also demonstrated the peripheral analgesic effect of opioids and showed that they block inflammatory hyperalgesia by stimulation of the arginine-NO-cGMP pathway in the primary nociceptive neuron.
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Pharmacological Reportsno. 6 (2016): 1293-1300
SCIENTIFIC REPORTSno. 1 (2016): 26955-26955
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