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个人简介
My research expertise and interest are in the area of cancer epigenetics which involves identifying the epigenetic changes responsible for carcinogenesis and translating clinically relevant biomarkers for diagnostic, prognostic and therapeutic use and delineate key cell and molecular events responsible for carcinogenesis. I am using cell lines, nude mice model and genome editing technologies to understand the regulation and biological function of DNA methylation regulated genes and miRNAs in the pathophysiology of cervical cancer using molecular and biochemical approaches. My focused research area includes (i) identification and characterization of DNA methylation regulated genes in cervical cancer, (ii) deciphering the mechanism by which DOC2B and chromosome 14 miRNA cluster act as a tumor suppressor in cervical cancer and (iii) exposomics of Bisphenol-A.
Our research work has led to the identification and establishment of new cancer-associated genes and pathways for early diagnosis and prognostic applications. Our group showed that genes such as ARHGAP6, DAPK1, DOC2B, HAND2, NKX2-2, NNAT, PCDH10, PROX1, PITX2, and RAB6C can be useful for early diagnosis for cervical and oral cancer of tongue (Tumour Biol. 2017 and Virchows Arch. 2017). We have shown for the first time the tumor growth regulatory function of the DOC2B gene in cervical cancer and developed a bioinformatics pipeline to analyze the bisulfite sequence data generated from Ion torrent sequencer (JBC. 2014 and Tumour Biol. 2017). We have sequenced the mitochondrial genome to identify the mtDNA mutations associated with cervical cancer and congenital cancer (Mitochondrion. 2014 and Mol Vis. 2012). Our studies have also led to the identification of methylation regulated miRNAs and their role in the pathophysiology of cervical cancer (Mol Carcinog. 2018, Life Sciences 2019, Gynecologic Oncology, 2019)
研究兴趣
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CLINICAL EPIDEMIOLOGY AND GLOBAL HEALTH (2024): 101546
MOLECULAR ONCOLOGY (2024)
Shreyas Hulusemane Karunakara, Vijayalakshmi Bhat, Manju Moorthy,Gopalakrishna Ramaswamy,Shama Prasada Kabekkodu, Nirmala Gollarahalli SannappaGowda,Varsha Dilip Shiragannavar,Divya Prasanna Kumar,Akila Prashant,Prashant M Vishwanath,Prasanna Kumar Santhekadur
crossref(2024)
Reproductive sciences (Thousand Oaks, Calif.)no. 5 (2024): 1420-1428
Clinical and Experimental Medicineno. 1 (2024): 1-18
Sriharikrishnaa Srinath,Padacherri Vethil Jishnu,Vinay Koshy Varghese,Vaibhav Shukla,Divya Adiga,Sandeep Mallya,Sanjiban Chakrabarty,Krishna Sharan, Deeksha Pandey,Aniruddha Chatterjee,Shama Prasada Kabekkodu
Molecular Oncologyno. 6 (2024): 1608-1630
TOXICOLOGY (2024): 153791-153791
Biochimica et Biophysica Acta (BBA) - Molecular Cell Researchno. 4 (2024): 119708-119708
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