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Considering his great interest in novel transition-metalcatalyzed reactions, the discovery of the Murai reaction was
not an unexpected event (Nature 1993, 366, 529). In this reaction, a ruthenium complex selectively activates the orthoC-H bond of an aromatic ketone, which had previously been
considered to be difficult and even impossible, and then
catalyzes the addition of the C-H bond across the double
bond of an alkene. The Murai reaction is now associated
with impressive product yields, selectivity, and atom-economy, and is epoch-making in that it involves a catalytic, directed bond activation. Importantly, Prof. Murai clearly
showed that the C-H bond activation, i.e., oxidative addition, is not as difficult to achieve as was originally expected
(Bull. Chem. Soc. Jpn. 1995, 68, 62), which is a guiding principle in exploring the catalytic activation of inert bonds.
Prof. Murai has undoubtedly contributed to a quantum leap
in the development of the chemistry of inert bond activation (Acc. Chem. Res. 2002, 35, 826). As an additional note,
he edited the first book dealing with the chemistry of the
transition-metal-mediated activation of inert bonds (Activation of Unreactive Bonds and Organic Synthesis, SpringerVerlag, 1999), which is now considered to be a 'bible' for
those involved in research on bond activation. His work on
transition-metal catalysts has clearly changed the landscape of organic synthesis
not an unexpected event (Nature 1993, 366, 529). In this reaction, a ruthenium complex selectively activates the orthoC-H bond of an aromatic ketone, which had previously been
considered to be difficult and even impossible, and then
catalyzes the addition of the C-H bond across the double
bond of an alkene. The Murai reaction is now associated
with impressive product yields, selectivity, and atom-economy, and is epoch-making in that it involves a catalytic, directed bond activation. Importantly, Prof. Murai clearly
showed that the C-H bond activation, i.e., oxidative addition, is not as difficult to achieve as was originally expected
(Bull. Chem. Soc. Jpn. 1995, 68, 62), which is a guiding principle in exploring the catalytic activation of inert bonds.
Prof. Murai has undoubtedly contributed to a quantum leap
in the development of the chemistry of inert bond activation (Acc. Chem. Res. 2002, 35, 826). As an additional note,
he edited the first book dealing with the chemistry of the
transition-metal-mediated activation of inert bonds (Activation of Unreactive Bonds and Organic Synthesis, SpringerVerlag, 1999), which is now considered to be a 'bible' for
those involved in research on bond activation. His work on
transition-metal catalysts has clearly changed the landscape of organic synthesis
Research Interests
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Proceedings of the Japan Academy, Series Bno. 5 (2011): 230-241
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