基本信息
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Bio
At the invitation of the Spanish Government, between 1999 and 2004 Professor Moncada conceived, designed and developed the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid.
In the last decade his work has focused on the interaction between NO and cytochrome c oxidase, the terminal enzyme of the mitochondrial electron transport chain. This work has established the role of NO as a physiological regulator of cell respiration and a cell signalling molecule in response to stress. In addition, he has shown that interactions between NO and oxygen at the level of cytochrome c oxidase might also initiate pathophysiology. His recent finding that NO is involved in mitochondrial biogenesis has implications for the understanding of metabolic syndrome, type-2 diabetes and obesity.
His interest in glycolysis has led him, in recent years, to the identification of a molecular mechanism that coordinates cell proliferation with the provision of the metabolic substrates required for this process. This research has significant implications for the understanding of normal and abnormal cell proliferation, for example in cancer.
From 2010 to 2013 he ran an independent VIB-K.U. research group in the VIB Vesalius Research Center in Leuven, Belgium. The research team, which he ran concurrently with his laboratory at the WIBR, focused on basic research to unravel the molecular basis and explore the therapeutic potential of the link between metabolism and cell proliferation.
From January 2014 Prof Moncada is Professor of Translational Medicine and Strategic Advisor at the University of Manchester and is Emeritus Professor of Experimental Biology and Therapeutics at University College London.
Prof. Moncada’s research has had a major impact, as shown by his standing in the international citation indexes and his acknowledgement as the most cited UK scientist in biomedicine in the 1990s. In 2010 he received a Knighthood from Her Majesty the Queen in recognition of his services to Science.
Research Interests
Papers共 289 篇Author StatisticsCo-AuthorSimilar Experts
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Marco T. Medina,Ley Sander,Salvador Moncada, Yolly Molina, Isaac Zablah, Marcio Madrid, Luis Rodriguez-Salinas, Jose A. Lara-Pinto, Vanessa Sirias, Hebel Urquia,Marco Medina-Montoya, Susy Handal,
Journal of the Neurological Sciences (2023): 122383
bioRxiv (Cold Spring Harbor Laboratory) (2021)
Journal of the Neurological Sciences (2020): 116972-116972
Proceedings for Annual Meeting of The Japanese Pharmacological Societyno. 0 (2018): PO2-7
ENDOTHELIUM AND CARDIOVASCULAR DISEASES: VASCULAR BIOLOGY AND CLINICAL SYNDROMESpp.5-10, (2018)
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