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His early clinical interests were in the management of acute and chronic kidney failure, helping to adapt hemodialysis and kidney transplantation to infants and small children. His more basic research efforts initially focused primarily on diabetic kidney disease, the cause of nearly half of chronic kidney failure in the Western world. Initially in animal studies and then in research kidney biopsies in humans, he helped to describe the structural changes in the kidney in diabetes that lead to kidney failure. He explored the cellular basis of diabetic kidney disease (DKD) in a series of studies in cells cultured from patients with diabetes. He showed that the structural changes of DKD were reversible by cure of insulin dependent (type 1) diabetes by pancreas transplantation. He was Principle Investigator of two large international multicenter NIH funded clinical treatment trials in type 1 diabetes. In the last 12 years he has also studied a relatively rare form of inherited kidney injury related to Fabry disease and has helped to elucidate the kidney structural basis of this disorder.
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Papers共 621 篇Author StatisticsCo-AuthorSimilar Experts
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISMno. 8 (2024): 2124-2135
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGYno. 12 (2023): 1953-1964
Transplantation of the Pancreaspp.817-830, (2023)
Springer eBookspp.817-830, (2023)
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The Journal of clinical investigationno. 11 (2023)
Clinical journal of the American Society of Nephrology : CJASNno. 1 (2023): 44-55
Molecular Genetics and Metabolismno. 2 (2023): 107234
Endocrinesno. 3 (2023): 548-557
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