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Bio
My laboratory focuses on the molecular basis of population heterogeneity in Mycobacterium tuberculosis (Mtb) and the extent to which differences between mycobacterial cells contribute to differences in disease and treatment outcomes. Our work combines bacterial genetic approaches with high throughput methodologies including population genomics, ssRNAseq and quantitative live cell imaging to define the molecular mechanisms by which Mtb generates diversity and how this diversity enables the bacterium to survive subsequent selective forces including antibiotics and immune selection. We further seek to understand the impact of host immune responses on the interaction of Mtb with the infected host, again working at both single cell and genomic levels. My work engages a broad network of collaborators including experts in technologies to assess single cell behavior at MIT and MGH, experts in sequencing methodologies at the Broad Institute and experts in human immunology at the Ragon Institute, where I am the outgoing Director of the TB Program.
Research Interests
Papers共 179 篇Author StatisticsCo-AuthorSimilar Experts
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Brain : a journal of neurology (2024)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 14 (2024): e2403321121-e2403321121
Joshua M. Peters,Hannah P. Gideon,Travis K. Hughes, Cal Gunnarson,Pauline Maiello,Douaa Mugahid,Sarah K. Nyquist,Joshua D. Bromley,Paul C. Blainey,Beth F. Junecko, Molly L. Nelson,Douglas A. Lauffenburger,
crossref(2024)
bioRxiv : the preprint server for biology (2024)
Ming-Zhi Deng,Qingyun Liu, Shu-Jun Cui, Yi-Xin Wang, Guoliang Zhu, Han Fu,Mingyu Gan,Yuan-Yuan Xu,Xia Cai, Sheng Wang,Wei Sha,Guo-Ping Zhao,
Proceedings of the National Academy of Sciences of the United States of Americano. 34 (2024): e2322938121-e2322938121
biorxiv(2024)
Cecilia Webber, Virginia Glick, Morgan Martin, Cecilia Kim, Maryam Ahmad, Lauren Simmons,Sunghee Bang,Michael Chao, Nicole Howard,Sarah Fortune,Lalit Beura,Seo Yoon Lee,
biorxiv(2024)
crossref(2023)
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Author Statistics
#Papers: 181
#Citation: 12429
H-Index: 54
G-Index: 111
Sociability: 7
Diversity: 3
Activity: 108
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