Lim is a pioneer in MSC exosome research and technology, having discovered MSC exosomes in 2008. She and her collaborators have rationalized and demonstrated several world "firsts" in the efficacious use of MSC exosome efficacy against many diseases and injuries. She has also been a major driver in the development of MSC exosomes as the most technology-ready of all therapeutic exosomes.

Major research interests in natural and synthetic nano lipid vesicles with specific focus on their synthesis and purification, biochemical and biophysical characterisation, and diagnostic and therapeutic applications.