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Bio
The overarching goal of my research program is to uncover the mechanisms mediating how males and females differ in their immune responses to viral infection and vaccination. We hypothesize that sex chromosome complement and X-linked genes as well as sex steroids and signaling through sex steroid receptors are critical pathways modulating immune responses to viruses. We consider how immunological, hormonal, and genetic differences between males and females affect sex differences in susceptibility to viruses, including influenza, Zika, and SARS-CoV-2 viruses. We also study the mechanisms mediating altered immune responses and infectious disease pathogenesis during pregnancy. Our research indicates that non-pregnant females typically mount more robust immune responses than males, which can be beneficial for the efficacy of vaccines and clearance of viruses, but also can be detrimental by causing immunopathology.
Research Interests
Papers共 293 篇Author StatisticsCo-AuthorSimilar Experts
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Natureno. 8010 (2024): 37-40
MBIO (2024)
Andrew H Karaba,Trevor S Johnston,Evan Beck,Oliver Laeyendecker,Andrea L Cox,Sabra L Klein,David J Sullivan, COVID- Serologic Studies Consortium
Clinical microbiology reviewsno. 2 (2024): e0007323-e0007323
CELLno. 6 (2024): 1354-1357
Santosh Dhakal,Han-Sol Park,Kumba Seddu,John S. Lee,Patrick S. Creisher, Brittany Seibert,Kimberly M. Davis, Isabella R. Hernandez,Robert W. Maul,Sabra L. Klein
Anna Yin, Nadia Wang,Patrick J. Shea, Erica N. Rosser,Helen Kuo,Janna R. Shapiro,Katherine Z.J. Fenstermacher,Andrew Pekosz,Richard E. Rothman,Sabra L. Klein,Rosemary Morgan
medrxiv(2024)
MBIOno. 1 (2024): e0061823-e0061823
Kashif Shaikh, Melissa Bowman, Sarah M. McCormick, Linlin Gao, Jiawen Zhang, John Tawil,Arun Kapoor,Ravit Arav-Boger,Young Bong Choi,Andrew Pekosz,Sabra L. Klein,Matthew Lanza,
crossref(2024)
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Author Statistics
#Papers: 294
#Citation: 26579
H-Index: 69
G-Index: 162
Sociability: 7
Diversity: 4
Activity: 133
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