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个人简介
I am passionate about science and discovery research! I have been trained as a biochemist, molecular biologist and cell biologist. My current research interests are in molecular mechanisms of disease, including cancer. Our research has resulted in fundamental discoveries in two key fields of intense contemporary interest: cell death and ubiquitin-dependent protein modification. Some of our key discoveries include the Nedd genes, e.g. identification of one of the first mammalian caspases (Nedd2/caspase-2); a novel family of ubiquitin ligases (the Nedd4 family); and the ubiquitin-like protein Nedd8 that is involved in a protein-modification process, now widely known as Neddylation. We also discovered and characterised a large part of the Drosophila cell death machinery, identified Ndfip1 and Ndfip2 as adaptors/regulators of ubiquitin ligases and characterised a previously unknown autophagy-dependent cell death program during development. Our work has resulted in groundbreaking contributions to the understanding of many human ailments including cancer, cardiovascular and kidney diseases.
研究兴趣
论文共 332 篇作者统计合作学者相似作者
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Shannon Nicolson,Jantina A. Manning,Yoon Lim,Xin Jiang, Erica Kolze,Sonia Dayan, Ruchi Umargamwala,Tianqi Xu,Jarrod J. Sandow,Andrew I. Webb,Sharad Kumar,Donna Denton
Communications Biologyno. 1 (2024): 1-24
CELLSno. 4 (2024): 347
Swati Dawar, Mariana C. Benitez,Yoon Lim, Toby A. Dite, Jumana M. Yousef, Niko Thio,Sylvain Garciaz, Thomas D. Jackson, Julia V. Milne, Laura F. Dagley, Wayne A. Phillips,Sharad Kumar,
bioRxiv (Cold Spring Harbor Laboratory)no. 3 (2024): 1-12
Mithun Vinod Shah,Elizabeth Ngoc Hoa Tran, Syed Shah,Rakchha Chhetri,Anmol Baranwal,Dariusz Ladon,Carl Shultz,Aref Al-Kali,Anna L. Brown, Dong Chen, Hamish S. Scott,Patricia Greipp,
Blood Cancer Journalno. 1 (2023): 1-9
Sezin Dagdeviren, Megan F Hoang,Mohsen Sarikhani,Vanessa Meier, Jake C Benoit, Marinna C Okawa,Veronika Y Melnik,Elisabeth M Ricci-Blair,Natalie Foot,Randall H Friedline,Xiaodi Hu,Lauren A Tauer,
The Journal of biological chemistryno. 8 (2023): 105045-105045
Molecular and cellular biologyno. 7 (2023): 317-334
Autophagyno. 4 (2023): 863-882
Cell death and differentiationno. 5 (2023): 1097-1154
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