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Bio
My ongoing efforts to advance knowledge and address unmet medical needs are focused on the discovery and development of therapeutic and disease-prevention agents. I exploit to target pharmacological treatments to brain regions experiencing stroke selectively. This hit-to-lead development program is focused on discovering Sigma-1 receptor (S1R)-mediated regulators from repurposing drugs to identify therapeutics potentially capable of slowing the progression of stroke. My efforts are primarily pre-clinical and translational and are guided to discover and refine druggable properties for lead compounds by a mechanistic understanding of receptor systems and brain-derived neurotrophic factor (BDNF) signaling pathways that modulate brain inflammation and neurogenesis. As a result of this research, the U.S. Provisional Patent application is under the review process ( Title: Drug Repurposing For Delayed Treatment of Ischemic Stroke, Serial NO.: 63/308,259). Another area of ongoing research is to evaluate the treatment of adjuvant microRNA as a means of enhancing the effectiveness of tamoxifen in treating breast cancer. I discovered that one of the microRNAs used in our ongoing research associated with brain cancer could be of significant therapeutics. Most of all, current interest relates to the discovery and development of mechanistically unique eco-friendly, vertebrate-safe mosquito and tick repellents for the prevention of arthropod-borne disease transmission to humans, livestock, and pets (e.g., West Nile Virus, Dengue, Lyme disease, Malaria, and various types of encephalitis). This branch of research is premised on interrogating mechanistic and structure-activity-based hypotheses, often involving the probing of molecule interactions. I successfully completed the R21 project on the prevention of Zika transmission with personal protective measures as a project leader and PI. To expand the scope of work, I have carried out the project on octopamine receptor (OctR)-targeting compounds as repellents for tick-borne disease as a PI. With a record of accomplishment as an innovative scientist in Cell Biology, Neuroscience, and Pharmacology and experience with drug discovery and development projects, I am well prepared to lead this translational project aimed at discovering and developing the AD treatment.
Research Interests
Papers共 27 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
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期刊级别
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合作机构
FRONTIERS IN ENDOCRINOLOGY (2024): 1286066-1286066
IBRO Reports (2019): S552
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Author Statistics
#Papers: 28
#Citation: 542
H-Index: 13
G-Index: 22
Sociability: 4
Diversity: 3
Activity: 3
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