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Bio
To gain experience in cross-species analyses using mouse models and clinical samples, I moved to Herbert Irving Cancer Centre, Columbia University, which led to the identification of 3 ageing-associated gene signatures that were highly predictive in stratifying indolent Gleason 6 and 7 prostate cancers from lethal subtypes. I returned to the UK to work at the Wellcome Trust Centre for Human Genetics, University of Oxford, exploring the role of perturbed BMP and Notch signalling in stem and progenitor cells in colorectal cancers.
Currently, my lab at NDCLS is working on understanding somatic stem cell ageing and how this impacts tissue function and tumorigenesis. We have an exciting new addition to our model system, that of the longest-lived rodent, the naked mole-rat, that maintains optimal physiological function and high fecundity for most of its life. Naked mole rats also do not exhibit an increase in age-related diseases and have a very low incidence of cancers. Unravelling novel homeostatic mechanisms associated with extended healthspan and longevity in naked mole rats holds great potential for ameliorating age-related pathologies.
Currently, my lab at NDCLS is working on understanding somatic stem cell ageing and how this impacts tissue function and tumorigenesis. We have an exciting new addition to our model system, that of the longest-lived rodent, the naked mole-rat, that maintains optimal physiological function and high fecundity for most of its life. Naked mole rats also do not exhibit an increase in age-related diseases and have a very low incidence of cancers. Unravelling novel homeostatic mechanisms associated with extended healthspan and longevity in naked mole rats holds great potential for ameliorating age-related pathologies.
Research Interests
Papers共 19 篇Author StatisticsCo-AuthorSimilar Experts
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EJ. Mulholland,HL. Belnoue-Davis,GN. Valbuena,N. Gunduz, A. Ligezal, S. Biswasl, E. Gil Vasquez, S. Omwengal, N. Nasreddinl,M. Hodder,LM. Wang,S. Irshad,
crossref(2024)
ONCOGENEno. 10 (2023): 782-782
Shamir Montazid,Sheila Bandyopadhyay,Daniel W. Hart,Nan Gao,Brian Johnson, Sri G. Thrumurthy,Dustin J. Penn,Bettina Wernisch,Mukesh Bansal,Philipp M. Altrock,Fabian Rost, Patrycja Gazinska,
Nature Communicationsno. 1 (2023): 1-20
William Dalleywater,Alexander V. Predeus,Batuhan Cakir,Pavel Mazin,Jayakumar Vadakekolathu,Sergio Rutella, Marian L. Meakin,Alison A. Ritchie, Shamir Montazid,Sara Cuevas Ocaña,Nadine Holmes,Victoria Wright,
biorxiv(2023)
The Journal of Pathology (2017)
JOURNAL OF BIOLOGICAL CHEMISTRYno. 2 (2015): 888-888
Nature Medicineno. 1 (2014): 62-70
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