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Bio
An international leader in the area of nutrition, obesity, metabolism and cancer, his lab focuses on the molecular and metabolic mechanisms underlying obesity-cancer associations, and the impact of obesity- energy balance modulation (eg, calorie restriction and exercise) or pharmacologic agents on cancer development, progression, and responses to chemotherapy. Primarily using genetically engineered mouse models of breast cancer (recently in parallel with several clinical trials), colon cancer and pancreatic cancer, Dr. Hursting has identified the IGF1/Akt/mTOR and NF-kB signaling pathways as key targets for breaking the obesity-cancer link. His publications establish causal links between obesity, cancer and several systemic factors (including IGF-1, insulin, leptin and IL-6) and components of their downstream signaling pathways (including mTOR and NF-kb).
Research Interests
Papers共 571 篇Author StatisticsCo-AuthorSimilar Experts
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Michael F. Coleman,Eylem Kulkoyluoglu Cotul,Alexander J. Pfeil,Alyssa N. Ho,Emily N. Devericks, Muhammad H. Safdar,Hao Chen, Numair Attaar,Violet A. Kiesel,Dorothy Teegarden,Stephen D. Hursting,Michael K. Wendt
Cancer Researchno. 6_Supplement (2024): 1790-1790
Elaine M. Glenny,Alyssa N. Ho,Violet A. Kiesel, Fangxin Chen,Claire E. Gates,Evan M. Paules, Ruihan Xu, C. Alex Holt,Michael F. Coleman,Stephen D. Hursting
bioRxiv the preprint server for biology (2024)
Alyssa N Ho,Violet A Kiesel,Claire E Gates, Bennett H Brosnan, Scott P Connelly,Elaine M Glenny,Alyssa J Cozzo,Stephen D Hursting,Michael Francis Coleman
Cellsno. 10 (2024): 806
Elaine M. Glenny,Tengda Lin, Victoria M. Bandera,Biljana Gigic,Aik Choon Tan,Babak Mirminachi, Saratchandra S. Khumukcham, Alessandro Carpanese,Christy A. Warby, Olena Aksonova,Caroline Himbert,Jennifer Ose,
Cancer Researchno. 6_Supplement (2024): 2190-2190
Eylem Kulkoyluoglu Cotul, Muhammad Hassan Safdar,Sebastian Juan Paez,Aneesha Kulkarni,Mitchell G. Ayers,Hang Lin, Zilin Xianyu,Dorothy Teegarden,Stephen D. Hursting,Michael K. Wendt
MOLECULAR CANCER RESEARCHno. 3 (2024): 254-267
CANCER RESEARCHno. 3 (2024)
Elaine M. Glenny,Alyssa N. Ho,Violet A. Kiesel, Fangxin Chen,Claire E. Gates,Evan M. Paules, Ruihan Xu, C. Alex Holt,Michael F. Coleman,Stephen D. Hursting
Cancer Researchno. 6_Supplement (2024): 2189-2189
Cancer Researchno. 6_Supplement (2024): 1784-1784
Michael F. Coleman,Eylem Kulkoyluoglu Cotul,Alexander J. Pfeil,Emily N. Devericks, Muhammad H. Safdar, Marvis Monteiro,Hao Chen,Alyssa N. Ho, Numair Attaar, Hannah M. Malian,Violet A. Kiesel, Alexis Ramos,
Breast Cancer Researchno. 1 (2024): 1-20
Yuan-Yuan Li, Supradeep S Madduri,Erika T Rezeli, Charlene Santos, Herman Freeman Iii, Jing Peng,Susan L McRitchie,Wimal Pathmasiri,Stephen D Hursting,Susan J Sumner,Delisha A Stewart
Frontiers in nutrition (2024): 1356038-1356038
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