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I am an academic clinician with an interest in immunity and transplantation. Our research examines how locally made components of the defence system influence the acceptance of foreign tissue or cell grafts and whether the findings can be exploited for therapeutic and diagnostic purposes. Our work on the complement system of host defence has evolved new clinical tools that potentially detect or block activated components of the inflammatory response. These are currently being tested or adapted for use in organs and cells used for transplantation. A sugar signature found on damaged donor tissues that trigger the local inflammatory response has come from our work and is the next target for developing imaging and therapeutic agents. Our collaborations bring together basic concepts in immunology, stem cell biology, molecular genetics and imaging, and protein and cell therapeutics, with applications in diseases of the heart, kidney, liver, brain and eye.
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论文共 267 篇作者统计合作学者相似作者
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Anastasia Polycarpou, Tara Wagner-Gamble,Roseanna Greenlaw, Lauren A. O'Neill,Hataf Khan,Michael M Malim,Marco Romano,Dorota Smolarek,Katie J Doores,Russell Wallis,Linda S Klavinskis,Steven Sacks
biorxiv(2023)
Ka Keat Lim,Kenrick Ng,Sathiyaa Balachandran,Mark D. Russell,Amy Boalch, Alasdair Sinclair,Bolaji Coker, Krishna Vinnakota,Rashid Mansoor,Abdel Douiri,Lara V. Marks,Steven Sacks
FRONTIERS IN MEDICINE (2023): 1256712
Kun-Yi Wu,Bo Cao, Wan-Bing Chen,Weiju Wu,Shujuan Zhao,Xiao-Yun Min,Jurong Yang,Jin Han,Xia Dong,Na Wang,Yi Wu,Peter Garred,
Kidney internationalno. 3 (2023): 524-539
Anne Grunenwald,Poillerat Victoria, Revel Margot, Voilin Elodie, Robe-Rybkine Tania,Idris Boudhabhay,Steven H. Sacks,Florent Petitprez,Laurent Gilardin,Lubka Roumenina
Seminars in Immunopathologyno. 3 (2022): 391-391
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Idris Boudhabhay,Victoria Poillerat,Anne Grunenwald,Carine Torset,Juliette Leon,Marie V. Daugan, Francesca Lucibello,Khalil El Karoui, Amandine Ydee,Sophie Chauvet,Patrick Girardie,Steven Sacks,
Kidney Internationalno. 3 (2021): 581-597
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