Dr. Goodman and his colleagues at the University of Colorado had a major impact on the field of inborn errors of metabolism. Accomplishments included: (a) the development of gas chromatography-mass spectrometry (GC-MS) systems to screen for and characterize organic acidemias, which first became known with the description of isovaleric acidemia, (b) the first description of several inborn errors, most importantly glutaric aciduria type 1 and (c) the clinical, biochemical and molecular characterization of many inborn errors, including glutaric aciduria types 1 and 2 and several disorders of fatty acid oxidation.