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Bio
He became an expert in the studies of vascular oxidative stress such as NADPH oxidases, uncoupled endothelial NO synthase, xanthine oxidase and mitochondria.
Dr. Dikalov is a fellow of the American Heart Association (AHA) and serves on AHA committees. He has been an invited speaker locally and nationally at academic institutions and scientific meetings. He has authored over 156 original publications, including 46 as first author. These have appeared in high impact journals in cardiovascular sciences such as Journal of Clinical Investigation, Circulation Research, Hypertension, and Journal of Biological Chemistry.
His major accomplishments include discovery that essential hypertension is linked to mitochondrial dysfunction, overproduction of mitochondrial superoxide and formation of highly reactive oxidative stress products isolevuglandins. He developed mitochondria-targeted superoxide scavenger mitoTEMPO and mitochondrial scavenger of isolevuglandins mito2HOBA which improve mitochondrial function, reduce vascular dysfunction, and diminish hypertension. His work demonstrated pathogenic role of mitochondrial isolevuglandins including Sirt3 inactivation and promoting mitochondrial dysfunction. He demonstrated that mitochondrial cyclophilin D (CypD) has a previously unidentified role in vascular dysfunction and hypertension and supported the therapeutic potential of targeting CypD in this disease.
Dr. Dikalov directs the Free Radical in Medicine Core function and training of graduate students and medical fellows in measurements of oxidative stress using state-of-art methods such as Electron Spin Resonance and HPLC providing indispensable support for oxidative stress studies at Vanderbilt.
Dr. Dikalov is a fellow of the American Heart Association (AHA) and serves on AHA committees. He has been an invited speaker locally and nationally at academic institutions and scientific meetings. He has authored over 156 original publications, including 46 as first author. These have appeared in high impact journals in cardiovascular sciences such as Journal of Clinical Investigation, Circulation Research, Hypertension, and Journal of Biological Chemistry.
His major accomplishments include discovery that essential hypertension is linked to mitochondrial dysfunction, overproduction of mitochondrial superoxide and formation of highly reactive oxidative stress products isolevuglandins. He developed mitochondria-targeted superoxide scavenger mitoTEMPO and mitochondrial scavenger of isolevuglandins mito2HOBA which improve mitochondrial function, reduce vascular dysfunction, and diminish hypertension. His work demonstrated pathogenic role of mitochondrial isolevuglandins including Sirt3 inactivation and promoting mitochondrial dysfunction. He demonstrated that mitochondrial cyclophilin D (CypD) has a previously unidentified role in vascular dysfunction and hypertension and supported the therapeutic potential of targeting CypD in this disease.
Dr. Dikalov directs the Free Radical in Medicine Core function and training of graduate students and medical fellows in measurements of oxidative stress using state-of-art methods such as Electron Spin Resonance and HPLC providing indispensable support for oxidative stress studies at Vanderbilt.
Research Interests
Papers共 396 篇Author StatisticsCo-AuthorSimilar Experts
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AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGYno. 5 (2024): L539-L550
Circulation researchno. 11 (2024): 1451-1464
Circulation researchno. 10 (2024): 1276-1291
Gastroenterologyno. 5 (2024): S-175
International journal of molecular sciencesno. 12 (2024): 6498
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 1 (2023)
Pflugers Archiv : European journal of physiologyno. 7 (2023): 857-866
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 1 (2023)
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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