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个人简介
Dr. Dedhar has received several awards, including the Distinguished Scholar award from the Michael Smith Foundation for Health Research (MSFHR), the Terry Fox Cancer Research Scientist award of the National Cancer Institute of Canada (NCIC), UBC Distinguished Medical Research lecturer Award, the Canadian Cancer Society Robert L Noble Prize (2013) for “Outstanding achievement in Cancer Research”, as well as the 2018 UBC Killam Research Prize. He was elected Fellow of the Royal Society of Canada in 2018
Dr. Dedhar has pioneered a large body of work in the cellular and molecular biology of cell-extracellular matrix interactions. He is the discoverer of Integrin-Linked Kinase (ILK) which is an essential protein involved in the regulation of Integrin function and Integrin-mediated signal transduction. ILK deregulation plays a major role in cancer progression, kidney disease, inflammatory diseases, myelination disorders, and neurodegeneration. Mutations in the ILK gene have been associated with cardiomyopathy and cardiac disease. ILK is currently under investigation as a therapeutic target for these diseases.
Dr. Dedhar’s more recent work has involved establishing novel mouse models of cancer metastasis. These models have led to significant insights into the roles of tumour microenvironment and hypoxic stress as driving forces for metastatic potential. Dr. Dedhar’s research in this area has led to the identification of Carbonic Anhydrase IX (CAIX) as a therapeutic target in aggressive forms of breast cancer, brain cancer (glioblastoma) and pancreatic cancer. He has pioneered the development of a new inhibitor of CAIX, which has completed a Phase 1 clinical trial and is currently being evaluated in PhaseIb/II clinical trials
Dr. Dedhar has pioneered a large body of work in the cellular and molecular biology of cell-extracellular matrix interactions. He is the discoverer of Integrin-Linked Kinase (ILK) which is an essential protein involved in the regulation of Integrin function and Integrin-mediated signal transduction. ILK deregulation plays a major role in cancer progression, kidney disease, inflammatory diseases, myelination disorders, and neurodegeneration. Mutations in the ILK gene have been associated with cardiomyopathy and cardiac disease. ILK is currently under investigation as a therapeutic target for these diseases.
Dr. Dedhar’s more recent work has involved establishing novel mouse models of cancer metastasis. These models have led to significant insights into the roles of tumour microenvironment and hypoxic stress as driving forces for metastatic potential. Dr. Dedhar’s research in this area has led to the identification of Carbonic Anhydrase IX (CAIX) as a therapeutic target in aggressive forms of breast cancer, brain cancer (glioblastoma) and pancreatic cancer. He has pioneered the development of a new inhibitor of CAIX, which has completed a Phase 1 clinical trial and is currently being evaluated in PhaseIb/II clinical trials
研究兴趣
论文共 380 篇作者统计合作学者相似作者
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Muhetaer Mukaidaisi, Madiha Ahmed,Karl Grantham, Aws Al-Jumaily,Shoukat Dedhar,Michael Organ,Alain Tchagang,Jinqiang Hou, Ejaz Ahmed, Renata Dividino,Yifeng Li
crossref(2024)
Cancer Researchno. 6_Supplement (2024): 6002-6002
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024): 1-10
Paul C. McDonald,Shannon J. Awrey, Hossein Tavakoli, Rebekah Carroll,Zachary J. Gerbec,Joanna M. Karasinska,David F. Schaeffer,Daniel J. Renouf,Shoukat Dedhar
Cancer Researchno. 6_Supplement (2024): 1392-1392
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Yuanmei Lou, Paul C. McDonald,Arusha Oloumi,Stephen Chia, Christina Ostlund, Ardalan Ahmadi,Alastair Kyle,Ulrich auf dem Keller,Samuel Leung,David Huntsman, Blaise Clarke,Brent W. Sutherland,
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作者统计
#Papers: 374
#Citation: 37097
H-Index: 100
G-Index: 188
Sociability: 7
Diversity: 0
Activity: 2
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