Simon C Barry - Department of Biochemistry, University of Leicester

基本信息

Career Trajectory

Bio

Prof Barry has had a long standing interest in transcriptional regulation and how gene networks collaborate to shape a phenotype. He has applied this to the field of molecular immunology. Prof Barry is now using 3D genomics approaches to map the genetic risk of autoimmune disease to the regulatory elements in T cells that it affects in order to functionally define the defects in immune function caused by genetic risk, and has applied that to an IBD risk region in man, and type 1 Diabetes.

Research Interests

Papers共 200 篇Author StatisticsCo-AuthorSimilar Experts

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SARS-CoV-2 Infection and Childhood Islet Autoimmunity

Gregory J Walker,Kylie-Ann Mallitt,Maria E Craig,Pat Ashwood,Simon C Barry, James D Brown, Joanna Caguicla,Elizabeth A Davis,Emma E Hamilton-Williams,Leonard C Harrison,Aveni Haynes,Tony Huynh, Guinevere Martin, Kelly J McGorm,Grant Morahan, Zin Naing,Helena Oakey,Megan A S Penno, Andrea Sevendal,Richard O Sinnott,Georgia Soldatos,Rebecca L Thomson, Jason Tye-Din,Peter J Vuillermin, Emily J Ward,John M Wentworth,Peter G Colman,Jennifer J Couper,Ki Wook Kim,William D Rawlinson, ENDIA Study Group

JAMA pediatricsno. 5 (2025): 568-570

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LGR5: an Emerging Therapeutic Target for Cancer Metastasis and Chemotherapy Resistance

Wanqi Wang,Noor A. Lokman,Simon C. Barry,Martin K. Oehler,Carmela Ricciardelli

Cancer and Metastasis Reviewsno. 1 (2025): 1-23

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Mtor Inhibitors and Vaccine Response in Kidney Transplant Recipients

Griffith B Perkins, Matthew J Tunbridge, Cheng Sheng Chai,Christopher M Hope,Arthur Eng Lip Yeow,Tania Salehi, Julian Singer, Bree Shi, Makutiro G Masavuli, Zelalem Addis Mekonnen, Pablo Garcia-Valtanen,Svjetlana Kireta, Julie K Johnston, Christopher J Drogemuller, Beatrice Z Sim, Shane M Spencer,Benedetta C Sallustio,Iain Comerford,George Bouras,Daniela Weiskopf,Alessandro Sette,Anupriya Aggarwal, Vanessa Milogiannakis,Anouschka Akerman,Stuart Turville,Plinio R Hurtado,Tracey Ying,Pravin Hissaria,Simon C Barry, Steven J Chadban,Branka Grubor-Bauk,P Toby Coates

Journal of the American Society of Nephrology JASN (2025)

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Abstract LB450: Mechanisms of Acquired Resistance to AKT Inhibitor Capivasertib in AKT1 Mutant Patient Derived Breast Cancer Models

Sarah Mearns,Alex Pearson, Li-Xuan Sim,Rosalind Cutts,Prithika Sritharan,Heena Shah,Aditi Gulati,Stuart Williamson,Simon Barry,Elza De-Bruin,Nicholas C. Turner

Cancer Research（2024）

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Abstract LB115: Strong Antitumor Effect Elicited by Inhibition of AKT or FOXP3 in Combination with Anti-Pd-l1 in Pten Mutant Lung Squamous Cell Carcinoma

Maeva Houry,Miriam Redrado,Larissa Carnevalli,Simon Barry, Nuria Galan,Nerea Otegui,Sergio Leon,Luis Montuenga,Francisco Exposito,Alfonso Calvo

Cancer Research（2024）

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Ceralasertib Enhance Efficacy of Anti-Pdl1 Treatment by Modulating the Tumor Microenvironment in a IFNAR I Dependent Manner

Emilio Sanseviero,Devon Taylor,Sehmus Tohumeken, Mimi Mai,Ali Mostafa,Marta Milo,Kathy Mulgrew,Serge Fuchs,Alan Lau,Simon Barry,Mark Cobbold,Dmitry Gabrilovich

CANCER IMMUNOLOGY RESEARCHno. 10 (2024)

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Customizable and Open-Source 3D Printed Inserts for Controlled Release and Cell Culture Experiments

Kyle Brewer,Anthony Wignall, Alaa Bazeed,Batjargal Gundsambuu, Jarrod Kohlhagen, Jie Yan,Paul Joyce,Todd A. Gillam,Simon C. Barry,Anton Blencowe

ACS APPLIED POLYMER MATERIALSno. 19 (2024): 11813-11827

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Strong Antitumor Effect Elicited by Inhibition of AKT or FOXP3 in Combination with Anti-Pd-l1 in Pten Mutant Lung Squamous Cell Carcinoma

Maeva Houry,Miriam Redrado,Larissa Carnevalli,Simon Barry, Nuria Galan,Nerea Otegui,Sergio Leon,Luis Montuenga,Francisco Exposito,Alfonso Calvo

CANCER RESEARCHno. 7 (2024)

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Preclinical in Vivo Characterization Underpinning LGR5-targeting CAR-T Cells As a Cancer Immunotherapy

Jade Foeng,Timona Tyllis,Caitlin Abbott,Dylan McPeake,Emma Thompson,Veronika Bandara,Batjargal Gundsambuu,Silvana Napoli,Claudine Bonder,Iain Comerford, Tim Sadlon,Simon Barry,Shaun McColl

Cancer Researchno. 6_Supplement (2024): 56-56

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Targeting Macrophages and Regulatory T Cells Improves Response to Chemotherapy in High-Grade Serous Ovarian Cancer

Samar Elorbany,Chiara Berlato,Larissa Carnevalli,Simon Barry,Eleni Maniati,Jun Wang,Ranjit Manchanda, Julia Kzhyshkowska,Frances Balkwill

CANCER RESEARCHno. 6 (2024)

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